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Actinex is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by PPD, Actinex demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. Alza submitted a NDA to the FDA for Actinex for the treatment of premature ejaculation in December 2004. In October 2005, the company received a FDA Non-Approvable letter from the FDA, at which time they planned to work with regulators to address outstanding questions.

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Evaluation of the gastrointestinal hemorrhagic action of a new salicylic compound In this study, an integration vector containing the attP site and putative integrase gene mj1 of phage phiFC1 was constructed.

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In this contribution results will be discussed which were published only subsequent to 1970. Magnetic resonance direct thrombus imaging (MRDTI) is a novel technique which detects methaemoglobin in clot, allowing visualisation of thrombus without using intravenous contrast. Features of subepithelial lesions identified on endoscopic ultrasonography can be used to determine whether further diagnostic procedures such as endoscopic resection, fine needle aspiration, or core biopsy are required. A breaking of spatial symmetry of preexisting pattern plays a critical role in biological morphogenesis in development and evolution. New methods for performing immunoassays with these labels are described where appropriate.

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The second model demonstrates that high average water velocity and velocity gradient also enhance ooid growth. However, the prevalence and diversity of members of the genus Bifidobacterium in the infant intestinal microbiota has not yet been fully characterized, while some inconsistencies exist in literature regarding the abundance of this genus. Gz is the only pertussis-toxin-insensitive member of the inhibitory G protein subfamily. Selectivity of inhibition by anticancer agents of mouse spleen immune effector functions involved in responses to sheep erythrocytes.

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A three-component reaction forming naphthyridones--synthesis of lophocladine analogs. Chemical analyses of heavy metal contamination in sediments of the Venice Lagoon and toxicological implications. Evaluation of chemotherapy in advanced urinary bladder cancer with fast dynamic contrast-enhanced MR imaging.

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Paraganglioma masquerading as acute myocardial infarction and cardiogenic shock. Successful treatment of secondary aortoesophageal fistula after thoracic endovascular aortic repair

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The aminoacyl-tRNA synthetases link tRNAs with their cognate amino acid. Hypothalamic control of adrenaline secretion in response to insufficient glucose. The target cancer risk (TR) values suggested carcinogenic risk from Ni and As. Clinical assessment, measurement of outflow, and angiographic examination with digitally assisted assessment after 3 h of perfusion showed better results for retrograde perfusion in 8 of the 10 trials.

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We identified a heterozygous arginine to histidine p63 mutation, R279H, in all three affected individuals. Studies on the conformation of the anticodon loop of phenylalanine transfer ribonucleic acid. Moreover, therapeutic use of carnitine in several human diseases not involving carnitine deficiency per se has been indicated. To establish the correlation between the degree of vascularisation detected using power Doppler ultrasonography in digestive tract adenocarcinoma and the prognosis of these patients. DOC is the second largest source of bioreactive carbon in the environment and plays a key role in mediating microbial activity and generation of atmospheric CO(2).

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Gastroparesis (GP) patients suffer from recurrent symptoms of nausea, vomiting, early satiety, and abdominal pain. In order to identify the effect of CsA on influenza virus replication, a CypA-depleted 293T cell line, which was named as 293T/CypA-, was constructed. 5-Nucleotidase and alkaline phosphatase activity in septic and aseptic wounds of rats. At all but severely limiting sulfur supply, addition of a transgenic (Tg) sink for organic sulfur resulted in an increase in seed sulfur amino acid content. Gardening was also positively associated with physical activity and improved mental health and well-being.

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In the ultrastructural investigation of low ionic strength extracted muscle fibers, M protein could be localized in two stripes on both sides of the former M-line, suggesting a reduced attachment to the residual H-zone structure, whereas the specific removal of MM-CK resulted in the same dense staining pattern for M-protein within the M-line as observed in untreated fibers. Association between increased nuchal translucency and second trimester cardiac echogenic foci. Overall, these population-based data suggest an important relationship between problematic anger and numerous aspects of smoking behavior.

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Monitoring the biomechanical response of individual cells under compression: a new compression device. The hypopigmented variant constitutes a significant proportion of MF cases, especially in younger patients. We describe the clinical course, treatment and magnetic resonance findings during a four-year follow-up of a patient with acute multiple sclerosis of the Marburg type, treated with steroid and mannitol therapy, who survived the first bout. Fifty-two specimens of body cavity fluids from 52 patients were analyzed with conventional cytology, immunocytochemistry, and flow cytometric DNA ploidy methods to evaluate the most appropriate way of applying and interpreting immunocytochemistry and to evaluate the contribution of DNA ploidy analysis to conventional cytology in the diagnosis of body cavity fluids.

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These results suggest that the DHPG-LTD results from modulation of the presynaptic calcium currents by group I mGluRs. Thirteen patients were diagnosed with disseminated trichosporonosis over a 20 year period in Oita Medical University Hospital. During follow up, nine patients developed carcinoma in situ and/or invasive carcinoma. Curcumin attenuates gentamicin-induced renal oxidative damage in rats.

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Through this study, the authors aimed to estimate the prevalence of depressive disorders in Egyptian adolescent female students. The next generation of biologic agents: therapeutic role in relation to existing therapies in metastatic breast cancer. It is shown here that transformation of strawberry with the FaOMT sequence in sense and antisense orientation, under the control of the cauliflower mosaic virus 35S promoter, resulted in a near total loss of DMMF, whereas the levels of the other volatiles remained unchanged. A review of treatment of 43 cases of ovarian malignancy with special reference to chemotherapy.

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In this article, protein- and DNA-based methods employing western blots, enzyme-linked immunosorbant assay, lateral flow strips, Southern blots, qualitative-, quantitative-, real-time- and limiting dilution-PCR methods, are discussed. Enhancement of platelet aggregation and thrombus formation by arsenic in drinking water: a contributing factor to cardiovascular disease. Neither herpes varicella zoster immunocytochemical reactivity nor viral inclusions were seen. To explore how internal factors, such as organizational size, mission, ownership, and managerial communication and control structures, affect the delivery of primary care to older Americans across a wide variety of practice settings: ambulatory practices, hospitals, nursing homes, and home healthcare agencies.

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The objective of this study was to evaluate the association among dietary Mg, serum Mg, and diabetes in Chinese adults. Despite the widespread health impact of this process, the molecular mechanisms underlying the aging-specific decline in ovarian function are almost completely unknown. Laser microfabricated model surfaces for controlled cell growth.

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Immediately after the release of ischemia, ATP-MgCl2 (50 mumoles/kg) was given intravenously. Acute pancreatitis was induced by subcutaneous injections of caerulein (12 microg/kg) at 6-hour intervals for 2 days. Achalasia complicated by multiple intramucosal carcinomas: report of a case. In response to infection, numerous cytokines/chemokines are secreted by resident cells of the CNS and inflammatory leukocytes that participate in both host defense and disease.

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Assessment of both objective functioning and subjective appraisal of functioning will result in treatment suggestions that meet the patients needs. A simple correction factor for non-perpendicular magnetic resonance images proved useful in relating volume changes to known pressure changes within the carpal tunnel. Furthermore, MRI is more than just a single tool for extracting structural information. Local second-harmonic generation enhancement on gold nanostructures probed by two-photon microscopy.

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This behavior is qualitatively coherent with the oscillations observed in zeta potential values for increasing DPPC concentration. Moreover, unequal access to capital may mean a two-tier clinical information environment in the future. Fungal infection is increasingly recognised as an important cause of morbidity and mortality, especially in immunocompromised patients.

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Cell lines established from small cell lung cancer (SCLC), a neuroendocrine tumor, have low or absent expression of class I major histocompatibility complex antigens. The importance of studying circulating platelet aggregation in cerebrovascular stroke To determine whether actigraph placement affects sleep estimation in children.

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Electron microscopy revealed that ferritin-conjugated PNA bind not to the outer acrosomal and overlying plasma membranes, but specifically to the surface of the inner acrosomal membrane exposed by sonication. Blood samples were drawn at 12 and 24 clock hours at monthly intervals for the analysis of luteinizing hormone, follicle-stimulating hormone and testosterone. The immuno-fluorescence method has detected ILP in striated ducts of the salivary glands. Reduced fatty acid synthesis and desaturation due to exogenous trans10,cis12-CLA in cows fed oleic or linoleic oil. 2) The lymphocytes lack the enzyme responsible for the receptor-mediated degradation or a coupling factor between the receptor and the enzyme.

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Although somewhat controversial, there is good evidence that long-distance travel in general is a risk factor for venous thromboembolism, even in the absence of other risk factors. We propose that this downregulation of V(1A) receptors contributes to the attenuated responsiveness of blood pressure in response to vasopressin and, therefore, contributes to the circulatory failure in septic shock. Role of hemodynamic disorders of the lesser circulation in the pathogenesis of external respiratory insufficiency in late pregnancy toxemias Furthermore, there is no information on the effect of the PAE on the performance of the anaerobic digesters treating sludge.

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