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The previous version of GenTHREADER consisted of a simple neural network which was trained to combine sequence alignment score, length information and energy potentials derived from threading into a single score representing the relationship between two proteins, as designated by CATH. Applications using particular nuclei will then be described and related to other experimental work where appropriate.

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Polymorphism of the Cytochrome P4502C9 enzyme leads to warfarin hypersensitivity presumably due to decreased metabolism of the S-enantiomer. Au nanoparticles conjugated with underivatized mono-, oligo-, and polysaccharides were synthesized using our recently developed photocoupling chemistry.

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The findings indicated that, compared with native-born Belgians, immigrant groups from Turkey and Morocco were more likely to have poorer self-rated health. The authors compared the evolution of the pregnancy, of the labour and of the post-partum period in 75 patients who had cerclage for cervico-isthmial incompetence and in 68 mothers who had no pathology in the cervix (the control group). Mutually similar volumes are then grouped together by stacking them along an additional fourth dimension, thus producing a 4-D structure, termed group, where different types of data correlation exist along the different dimensions: local correlation along the two dimensions of the blocks, temporal correlation along the motion trajectories, and nonlocal spatial correlation (i.e., self-similarity) along the fourth dimension of the group. LXR agonists, T0901317 and 22(R)-hydroxycholesterol, dose dependently enhanced the suppressive effects of LXRs.

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Vasoactive agents induce loss of junctional integrity, a process that involves actin-myosin interaction. These 10 amino acids are highly conserved in mammalian, Xenopus, and Drosophila type I receptors. If the functional relations governing the strength of a conditioned reinforcer correspond to those obtained with other Pavlovian procedures (e.g., Kaplan, 1984), the termination of stimuli appearing early in the interval between successive food deliveries should be reinforcing. The purpose of this study was to identify the least painful circumcision method. Common set of genes regulates low-density lipoprotein size and obesity-related factors in Alaskan Eskimos: results from the GOCADAN study.

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Mediastinal bronchogenic cyst (MBC) is the most common primary cystic lesion of the mediastinum. This demonstrated that descending motor commands from higher brain centers have an effect on the cardiovascular response to exercise.

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It contains three overlapping promoters, two initiating transcription towards recF and one in the opposite direction. In addition, the protein synthesized in the presence of CST had significant levels of neuraminidase and hemagglutination activity suggesting that processing of the carbohydrate has a minimal role in the activity of the protein. It can be explored during the cardiac cycle and a transparency mode demonstrates coronary arteries, movement of the heart valves, and simultaneous blood-flow. We show that--as a family--these species have abundances in the diffuse ISM on the order of 10(-10) with respect to hydrogen, values consistent with their abundances in dense molecular clouds. Negative self-fulfilling prophecies, reflected at individual, interpersonal, institutional, and societal levels, play a critical role in creating and perpetuating unequal opportunities to learn.

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A baseline and 2-year follow-up clinical and CSF study of 86 subjects, including 22 MCI patients that declined to AD (MCI-AD), 43 MCI that did not deteriorate (MCI-MCI) and 21 controls (NL-NL). Addition of 10 mM dibutyryl-cAMP to the culture medium completely restored the wild-type phenotype in both mutant strains. The SsrA or tmRNA quality control system intervenes when ribosomes stall on mRNAs and directs the addition of a C-terminal peptide tag that targets the modified polypeptide for degradation. Granulocyte macrophage-colony stimulation factor (GM-CSF)-based vaccines have now been tested in several diseases in a variety of formulations.

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The PDLLA/PDOPA-DFO membrane was supportive for the proliferation of both MC3T3-E1 cells and HUVECs, and especially for HUVECs. Two extreme examples that illustrate the subcellular polarized nature of neurons and the tight regulation of ion channel localization can be seen at the axon initial segment and the node of Ranvier.

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Cell lines from gestational choriocarcinoma showed a slightly positive finding (negative by immunofluorescence but slightly positive by inhibition test), except for JaR which was negative. Laryngoscopy in bilateral vocal fold immobility: can you make a diagnosis? The other Flexner report: how Abraham Flexner was diverted from medical schools to brothels. Image-guided epidural blood patch as effective treatment of intracranial hypotension.

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Moreover, the field potential can be measured automatically, introducing a high throughput performance compared to the conventional microscopic observation. Neither the intrinsic nor extrinsic apoptotic PCD pathway was activated. Feminization of males, mostly by progestogens in some 45 cases, is unproven at present. Natural history of lower urinary tract symptoms in men--result of a longitudinal community-based study in Japan.

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In a simulation study, we evaluate the empirical coverage of these confidence intervals and rejection rates of the corresponding tests in finite samples. Regulation of heat shock protein 70 (HSP70) expression in oral submucous fibrosis is not known much, and the aim of this study was to evaluate HSP70 expression in oral submucous fibrosis and oral squamous cell carcinoma by immunohistochemical method and to understand the role of HSP70 in tumorigenesis. Intracellular viral capsid p24 staining showed abundant viral gene expression in BaL-infected SIRC cells expressing CD4 and CCR5. Early detection and management of vertical root fractures, or VRFs, remain a vexing issue that has caused needless suffering for patients as well as for dentists.

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Bariatric surgery for high risk patients: first staged laparoscopic biliopancreatic diversion with duodenal switch for severe obesity. Health-related quality of life was better in patients on HDF compared with patients on hemodialysis, especially compared with low-flux hemodialysis patients in most of the scales and in both dimensions: physical component scale and mental component scale. While the ultrasonographic pattern alone was too unspecific to establish the correct diagnosis, the colonoscopic findings were diagnostic of intussusception. Obstetric performance, perinatal outcome and risk of infection to the newborn in spontaneous and artificial rupture of membranes during labour. Reduction in ST use may be a viable approach for those oral moist ST users with no immediate quit plans.

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Optimisation of the operational conditions of trichloroethylene degradation using Trametes versicolor under quinone redox cycling conditions using central composite design methodology. The system was previously thought to be under simple continuous (i.e., single mode of operation) feedback control, but recent research has shown that it is under discontinuous (i.e., two stimulus-dependent modes of operation) feedback control by means of fast and slow processes. Apparently, monkeys remembered and used initial list-position information, but linkage allowed inference of an integrated serial relationship among items. No differences in the circulating concentrations of any of the hormones were observed between piglets of different sizes.

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ASSESSING ENVIRONMENTAL INEQUALITY: HOW THE CONCLUSIONS WE DRAW VARY ACCORDING TO THE DEFINITIONS WE EMPLOY. A 53-year-old woman was admitted to our hospital for chest abnormal shadow.

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Bone tumorigenesis induced by alpha-particle radiation: mapping of genetic loci influencing predisposition in mice. We postulated that treatment with antioxidant vitamins C and E would retard the progression of transplant-associated arteriosclerosis. Normal fasting plasma glucose and risk of prediabetes and type 2 diabetes: the Isfahan Diabetes Prevention Study. In this historical cohort study, the patients who had been transferred to Level I trauma center in southeastern Iran due to road traffic accidents with radiographic documented SCI were evaluated. Sporopollenin aggregation, which failed to anchor to the microspore plasma membrane, was deposited on the locule wall and in the locule at the uninucleate microspore stage.

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On the Advantages of an Amputation through the Thigh, either as a Preliminary Operation to, or, in some cases, instead of, Amputation through the Hip, where the Hip-joint is itself diseased and the Patient in very bad Condition. Reasons for an exchange between eastern and western approach to patients with HCC.

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This study is a retrospective outcomes analysis of two cases of MCC with data regarding clinical, histopathological, immunohistochemistry and also surgical, chimio and radiological treatment. Animals were divided into three groups and received bupivacaine and baclofen infusions at 20 or 1,000 microl/h or as a 1,000-microl bolus over 5 min every hour. Our results indicate that dementia with Lewy bodies results in cardiac sympathetic denervation and that iodine-123 metaiodobenzylguanidine myocardial scintigraphy is a sensitive tool for discriminating dementia with Lewy bodies from Alzheimer disease even in patients without parkinsonism. Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study.

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Our data provide substantial evidence for a model elucidating the molecular mechanisms of PKC-induced actin rearrangements. This review of the literature related to the role of the clinical nurse specialist was commissioned by the AACN in order to provide a comprehensive resource for advanced practice nurses. The bacterial flora of the upper respiratory tract and gut in children of nomad Lapps.

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Taken together, these results indicate that acute production of GABA(A)R-enhancing neurosteroids plays a key role in mediating the effects of ethanol on LTP. In contrast, a signal-region mutant form of ovalbumin (deletion, Gly1 to Ala39) was not detected in the periplasm despite being synthesized at the same level as the wild-type protein. Case of osteosarcoma of the mandible in a patient with fibrous dysplasia Campomanesia adamantium Peel Extract in Antidiarrheal Activity: The Ability of Inhibition of Heat-Stable Enterotoxin by Polyphenols. Cost-effectiveness of RespiGam at a university teaching hospital.

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The complex functions of the spatial interferograms formed by each single wavelength are constructed before performing the Fourier transformation to localize the scatters within a sample. The choice task was completed in a postal questionnaire by 162 unpaid carers of older people from 5 geographical locations in the United Kingdom. The ratios of factors in different parts of the brain, both in terms of the proportions of the total dispersity and in terms of weightings, provided data on regional and individual differences in electrical activity. Monoclonal antibody 54.2.8 stained the nuclei and cytoplasm of cells within the epidermis and epidermal appendages, as well as cells scattered throughout the dermis.

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Although antiproteinases such as the metalloproteinase inhibitor TIMP-3 are thought to play critical roles in preventing the overaggressive invasion of trophoblasts, the mechanism of antiproteinase regulation is unknown. The activity and/or amount of the NII protein kinase was significantly reduced in resting liver, which correlated with decreased specific activity of the liver RNA polymerase I. For OSA, although CPAP may reduce cardiovascular disease risk, its main benefit is symptom control. Vertebrate development requires progressive commitment of embryonic cells into specific lineages through a continuum of signals that play off differentiation versus multipotency. In five patients, a mesocaval shunt (MCS) was performed and in seven patients, a mesoatrial shunt (MAS) was carried out.

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infantum, instead of Leishmania braziliensis, the main agent of cutaneous leishmaniasis in Rio de Janeiro. The immune plasma derived from CV-immunized donors had a therapeutic effect in patients with tick-borne encephalitis. The HGF transfected MKN45 cells could stably express HGF mRNA, and secrete HGF protein to the cell culture median which was detected to exhibit normal function. Reserpine-induced rigidity in rats: drug effects on muscle tone from corpus striatum and nucleus accumbens. Their phosphodiesteric hydrolysis mediated by an activated phospholipase results in the generation of water soluble oligosaccharide species termed the inositol phosphoglycan (IPG).

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Interaction of uranyl with Se(IV) and Se(VI) in aqueous acid solutions by means of capillary electrophoresis. Here we report a simple and general methodology for switching the repulsive forces responsible for colloidal stabilization of MCC-capped NCs from long-range electrostatic to short-range steric through the formation of tight ionic pairs with cationic surfactants. The area of Gela was included among the 57 Italian polluted sites of national interest for environmental remediation because of its widespread contamination from a petrochemical complex. Toxemic patients presented increase of P and AP, and hypertensive patients diminution of A1-AT when compared with normal controls.

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The methodology of the fenclofenac clinical research programme and results obtained with particular reference to the therapeutic dose range. Analysis of the primary translational product and integrated DNA of a new feline sarcoma virus, GR-FeSV. Sciatic nerve segments were surgically resected and reconstructed, and the degenerative/regenerative outcomes were compared in wild-type and Vav2/3 double knockout mice. The late consequences of anthracycline treatment on left ventricular function after treatment for childhood cancer.

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The interaction of Fas with FasL results in a series of signal transductions which initiate apoptosis. Even today, alcoholics and chronically ill people in particular can develop symptoms of diet-related vitamin C deficiency. Studies of a Waldenstrom-type macroglobulin with rheumatoid factor properties. Interleukin-6: A Constitutive Modulator of Glycoprotein 130, Neuroinflammatory and Cell Survival Signaling in Retina.

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Neither an AT cell line nor a NBS cell line transformed with human papillomavirus genes E6 and E7 shows a G1 arrest. Altogether, these data suggest that the ubiquitin-proteasome (UP) system has a very complex interaction with the rotavirus life cycle, with both the ubiquitination and proteolytic activities of the system being relevant for virus replication. Given the association of IL28B genotype, specifically the rs12979860 single nucleotide polymorphism (SNP) based CC genotype, with HCV clearance, we studied its association with HIV control in 172 African American HIV subjects and 173 race-matched controls. However, the available evidence is insufficient to rule out the possibility that there is an optimal dosage schedule for ultrasound therapy that may be of benefit. This resulted in alternating phases of normal, hyper-, hypo- and again hyper-gravity.

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Observations on the role of immune antibody in protection in enteric infections. UTI preconditioning can partly adjust abnormal expression of genes in the brain tissue of rat with sepsis in the presence of excessive inflammation and immune suppression. The pharmacokinetics, toxicity and activity are clearly dependent on the type of amphotericin B formulation. Umbilical Nodule with Cyclical Bleeding: A Case Report and Literature Review of Atypical Endometriosis.