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Duodart (Dutasteride)

Duodart, a synthetic 4-azasteroid, is a selective and competitive inhibitor of both type 1 and type 2 5-alpha-reductase isoenzymes approved for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) who have an enlarged prostate. It has been demonstrated to be effective as monotherapy, or in combination with the alpha-adrenergic antagonist (α-blocker), tamsulosin, in several randomized, double-blind, placebo controlled trials and their open-label extensions. Treatment with Duodart is generally safe and well tolerated. Duodart has become established in the management of men with lower urinary tract symptoms (LUTS) and reduces the risk of acute urinary retention and surgery related to BPH. Duodart may also have a role as a chemopreventive agent in the future as emerging evidence demonstrates a reduced risk of prostate cancer with this agent.

Other names for this medication:
Dutasteride, Deetor, Duodart, Duprost, Dutagen, Dutas, Dutasterida, Dute, Veltride,

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Nifedipine with and without propranolol in the treatment of myocardial ischemia: effect on ventricular arrhythmias and recovery of regional wall function. Therefore, AAV-TGFbeta(1) and AAV-TGFbeta(3) could be used for the earlier dedifferentiated NP cells, and the TGFbeta(3) could be used as the objective gene for the later dedifferentiated NP cells. Surgical and histological observations on atypical median cervical cysts

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The resulting curriculum is available on the Web sites of the AAN ( and the American Society of Neuroimaging ( and will be updated as the need arises through evolving technology or breadth of applications. Reversible photochemical conversion of helicity in self-assembled nanofibers from a 1,omega-thymidylic acid appended bolaamphiphile. Analysis of the PFGE patterns divided the collection into 15 types, while PCR techniques identified 11 distinct strain patterns.

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Therefore, the sheep is a useful animal model to study physiological events taking place in the lymphoid system, and in vivo studies in this species will continue to offer a great potential for research of biological relevance and supplement the research done on the in vitro manipulation of cells and biological products related to the immune system. Thus we evaluated our experience focusing on safety and tolerance of early postoperative jejunal feeding and possible risk factors for gastrointestinal adverse effects. Overall survival (OS) and progression-free survival (PFS) were assessed in children with and without metastasis.

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Polydimethylsiloxane (PDMS) elastomer is used in a wide range of biomaterial applications including microfluidics, cell culture substrates, flexible electronics, and medical devices. Infants at risk for development of brain white matter lesions can be identified by the concentrations of interleukin-6 and interleukin-1beta in amniotic fluid. Development of an analysis system for 24-hour blood pressure and heart rate variability in the rat.

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Recommendations from a workshop on Space Neuroscience Research held in Paris on April 22-24, 1997 are summarized. The Effect of Education on Old Age Cognitive Abilities: Evidence from a Regression Discontinuity Design. Protein kinase C beta (PKCbeta), a pivotal enzyme in B-cell signaling and survival, is overexpressed in most cases of mantle cell lymphoma (MCL). Moreover, recovery of cardiac function was significantly worse in hearts that had not been pre-treated with cariporide.

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11C-harmine as a tracer for monoamine oxidase A (MAO-A): in vitro and in vivo studies. Recognizing and avoiding intercultural miscommunication in distance education a study of the experiences of Canadian faculty and aboriginal nursing students.

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Three examples--from managed care, deinstitutionalization, and physician remuneration--demonstrate the need to empirically examine seemingly obvious assumptions about health patterns and trends, and the lessons to be learned when assumptions are proved incorrect. Research is needed to assess to what extent these EEG patterns are indicative of cerebral perfusion deficits. The transcription region for the lacBl was identified on this fragment with promoter- and terminator-probe plasmids. The effect of three variables on the verbal problem solving of educable mentally handicapped children.

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Intraduodenal pHgraphy was used in experiments on thyroidine fed dogs with duodenal fistulas to study the time course of pH modulations without regard for, and during digestion. However, some people are still concerned about the side effects or have been told that hair removal laser is not possible in darkly pigmented skin. In the following intramolecular Heck reaction, the tetracyclic ring system was formed to give 4, from which the synthesis of desogestrel (2) was furnished. coli K12 (P155) with isolates not harboring such a plasmid, no significant difference was observed in their ability to receive the Ent plasmid.

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The aim of this study was to investigate different aluminium test preparations regarding an optimal compound and an optimal test concentration. In contrast to previous reports that DEP is exclusitely hydrolyzed by a secreted nonlysosomal acid phosphatase, enzyme reaction product was present in supranuclear and basal lysosomes.

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Demonstration and structure of the microtubular system in Toxoplasma gondii Induction of TNF-alpha, uPA, IL-8 and MCP-1 by doxorubicin in human lung carcinoma cells. Results and hemodynamic changes after interposition mesocaval shunt. In all studies, the chain-retrieval model yielded better fits and predictions than statistical models of event choice. The purpose of this study was to describe and correlate the types of glomerular diseases reported in native kidney biopsy specimens and their clinical presentations in Iranian children.

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Introduction of normal serum or leucocytes into irradiated animals apparently did not reduce damage to the mechanism regulating the rate of antibody synthesis. Cholangiolocellular carcinoma (CoCC), now classified by the World Health Organization as a subtype of combined hepatocellular-cholangiocarcinoma, is currently regarded as a subtype of peripheral-type ICC. The remaining challenges of cell therapy of heart failure are also presented. Prehospital diagnosis was established by portable blood analyser and an early antidote with 4 MP treatment initiated in out-of-hospital setting.

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The initial clinical stage and grade remain the main determinant factors in survival irrespective of the treatment. Therefore, MCAM can be used not only as a molecular marker to determine the prognosis of ovarian cancer but also as a therapeutic target in metastatic ovarian cancer. Case of bilateral pneumolabyrinth presenting as sudden, bilateral deafness, without temporal bone fracture, after a fall. Is the quality of the patient-provider relationship associated with better adherence and health outcomes for patients with HIV?

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D-Mannose, which was the most effective nonphosphorylated sugar inhibitor, was capable of inhibiting all cell-mediated cytotoxic mechanisms tested (NK, ADCC, monocyte, and CTL) and its action did not appear to be solely due to an impairment in the recognition event. Measurements were taken during silence, phonation tasks, and while reading, with comparisons made between both study groups. To be recycled, glycerophosphoinositol enters the cell through the permease encoded by GIT1. The results of this study indicate that participants were perceived as significantly younger than their real ages, and male and female singers were perceived to be significantly younger than male and female nonsingers. This is the first report of such a complication in renal cell carcinoma.

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However, the differences between two groups were less clear in chloride and total protein. Duodenal ulcer is regarded as the end result of alterations in which Helicobacter pylori (HP) plays a major role as a pathogenetic agent. These techniques, combined with whole genome amplification that non-specifically amplify small amounts of starting DNA, offer exciting new opportunities for the study of malaria genetics. Manic Psychosis and Catatonia Stemming from Systemic Lupus Erythematosus: Response to ECT. In view of the veterinary and potential medical importance of LIV, a rapid and precise detection method for routine use that employs the TaqMan reverse transcription polymerase chain reaction (RT-PCR) has been developed to detect LIV RNA extracted from field samples.

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Critical illness myopathy unrelated to corticosteroids or neuromuscular blocking agents. Compared with negative controls, systemic sensitization and airway allergen challenges induced high serum levels of allergen-specific IgE, predominant Th2-type cytokine production, airway inflammation and development of in vivo airway hyperreactivity. The study was a prospective randomized controlled trial comparing fetal-neonatal and maternal outcomes in 300 women with gestational diabetes. forsythus by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and they were clearly recognized by sera from patients with adult and early-onset periodontitis in Western immmunoblot analysis.

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Stimulating action of hematoporphyrin on motor coordination and resistance to fatigue in rats Physical compatibility of milrinone lactate injection with intravenous drugs commonly used in the pediatric intensive care unit. Each examination was performed independently by a physician experienced in echocardiography, unaware of the results found by the alternative device. Copy number alterations can help identify patients with rectal cancer who are at risk of lymph node metastasis after chemoradiation.

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In particular, mode partition noise (MPN) associated with use of a Fabry-Perot laser diode can be a significant problem in a fiber-based system. A case of mucocutaneous leishmaniasis is described in a Japanese patient who had never been abroad, suggesting either contact with an infected person from Brazil or the presence in Japan of indigenous cutaneous leishmaniasis. All patients who underwent caesarean section between 22 and 28 weeks of gestation were included, regardless of the indication of caesarean section, their gender and type of pregnancy (single or multiple). Proceedings of the F4.1, F4.2, F4.5, F4.7, F4.8 and F4.10 Meetings of COSPAR Scientific Commission F which were held during the Thirtieth COSPAR Scientific Assembly, Hamburg, Germany, 11-21 July 1994.

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This study on 111 cases of early pregnancies confirms the usefulness of immunohistochemistry and cytometry but demonstrates the importance of the combination of both techniques to assist histology for the best reliable diagnosis. Alternariol methyl ether was weakly mutagenic to strain TA98 (without metabolic activation). Single-dose ciprofloxacin versus 3 days of norfloxacin in uncomplicated urinary tract infections in women.

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Genome scanning of Corynebacterium glutamicum ATCC13032 revealed the presence of five different genes encoding enzymes belonging to three putative trehalose biosynthesis pathways (OtsAB, TreYZ, TreS). Effect of isoprenaline on experimentally produced immunologic cardiac lesions.

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Reproductive hormones in breast cancer bone metastasis: The role of inhibins. The Id proteins do this by associating with the ubiquitous E proteins and preventing them from binding DNA or other transcription factors. melas shows a remarkably short dispersal from typical larval breeding places associated with mangrove swamps and it is definitely more zoophilic and exophilic than An. In Vivo Effects of Pichia Pastoris-Expressed Antimicrobial Peptide Hepcidin on the Community Composition and Metabolism Gut Microbiota of Rats. We generated mice lacking renin (Ren1c) using embryonic stem cells from C57BL/6 mice, a strain prone to diet-induced obesity.

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A 4-week toxicity study of magnesium sulfate administered by 24-hr intravenous infusion at the dosage levels of 0, 12.5, 50 and 100 mg/kg/hr in female beagle dogs was conducted. The PTG-mediated response engaged a mechanism similar to that initiated by extracellular ATP acting via the P2X(7) receptor. Atrial defibrillation using low energy between two intracardiac catheters with an electrical field between the right and left atria and the protocol used is feasible in patients with persistent spontaneous AF.

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On the technic of intravascular administration of solutions to chick embryos The activity changes are paralleled by similar changes in the steady-state amounts of coproporphyrinogen oxidase protein determined by immunoblotting and the steady-state concentrations of coproporphyrinogen oxidase mRNA estimated by in vitro translation/immunoprecipitation. The cases illustrate the heterogeneity of nonendemic, idiopathic ATLL, including the presence of mediastinal masses and more heterogeneous immunologic markers than endemic cases, and represent the two youngest cases of ATLL yet described.

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Activation of nuclear factor kappaB: potential role in metallothionein-mediated mitogenic response. We review the various drugs known to induce injury and the various patterns of injury seen. Contribution to the knowledge of the morphology of the human endometrium Traditionally, the immediate treatment of patients with differentiated thyroid carcinoma (DTC) after total thyroidectomy (TT) is thyroid remnant ablation (TRA) with 131I, during hypothyroidism.

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Mutational analysis of the predicted active site cysteine (Cys161) within mouse Apg10p shows that mutant Apg10pC161S, which can form a stable intermediate with Apg12p, inhibits Apg12p conjugation even in the presence of Apg7p, while overexpression of Apg7p facilitates formation of an Apg12p-Apg5p conjugate. Allogeneic bone marrow transplantation for erythrophagocytic lymphohistiocytosis. The importance of developing prevention and treatment for PTSD in medically ill children and adults includes increased morbidity and mortality (e.g., nonadherence to medications) and psychiatric sequelae and decreased quality of life. This makes the high-dose methotrexate regimen a treatment modality for malignant tumors without any side effects.

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Bayesian networks provide a valuable aid for representing epistemic relationships in a body of uncertain evidence. Cancer advancement, manner of treatment and survival were assessed in patients with NSCLC. Identification and characterization of a yeast homolog of U1 snRNP-specific protein C. Kinetics of phagocytosis of Chlamydia psittaci by mouse fibroblasts (L cells): separation of the attachment and ingestion stages. Environmental context effects of background color in free recall.

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This study examines c-kit expression in uterine endometrial stromal sarcomas, leiomyomas, and leiomyosarcomas using immunohistochemistry. Data analysis was based upon the NINCDS-ADRDA diagnostic criteria of AD. Internal carotid artery in rostral epidural rete mirabile in animals of the suborder of Ruminantia. Soluble interleukin-6 receptor activates the human papillomavirus type 18 long control region in SW756 cervical carcinoma cells in a STAT3-dependent manner. We evaluated the relationship between the lowest current amperage used to obtain a motor response, the success rate and the incidence of neurological complications with peripheral nerve blocks (PNB) in pediatric patients under general anesthesia.

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Calcium oxalate crystals in fetal bovine serum: implications for cell culture, phagocytosis and biomineralization studies in vitro. In both frogs, the thickness of the outer longitudinal and inner circular layers of smooth muscle changed before and after the esophago-gastric junction.

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