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Elucidation of obesity susceptibility genes through genome-wide and candidate gene approaches provides great promise in ultimately determining the genetic underpinnings of obesity. Demographics as well as other personal information were also collected. This review includes five parts, the statistical results of the scientific papers published in 15 domestic and a few foreign periodicals which are closely related to chromatography and presented on 1997 Beijing Conference and Exhibition on Instrumental Analysis and the 11th National Symposium of Chromatography, about chromatographic theory, GC, LC and CE.

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Reflection of a linearly chirped, supercontinuum optical pulse from a gold film with changing surface temperature induced by an ultrafast pump pulse allows the thermal transients to be encoded onto the spectrum of the probe pulse. We screened chromosomal deficiencies for suppression of a gain-of-function mutation tor (tor(GOF)), which led to the identification of 26 genomic regions that, when in half dosage, suppressed the defects caused by tor(GOF). Mechanisms of post-radiation injury: cerebral microinfarction not a significant factor. These include one patient each with carcinoma of the left kidney, gastric lymphoma, and granulomatous colitis. Hemorrhage from the gastrointestinal tract associated with hemorrhagic diathesis in children

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The regression coefficient (H3 mRNA-LIs against the Ki-67-LIs) was 0.33 for epithelial cells and 0.49 for stromal cells, suggesting that the cell cycle time was longer for epithelial cells than for stromal cells. Buffer zones can play important roles in agricultural habitats, both in the protection of off-crop habitats from pesticide and fertiliser drift and run-off, and in providing important areas of non-crop habitats. Hypoaldosteronism as a cause of hyperkalemia and syncopal attacks in a patient with complete heart block. Polyandry was beneficial as it increased the probability of pregnancy, possibly to avoid genetic incompatibility.

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Construction and characterization of a recombinant ovine lentivirus carrying the optimized green fluorescent protein gene at the dUTPase locus. Microbiological assessment included, for each woman, cultures from vagina/cervix, urine and placenta. To evaluate the presence of peripapillary retinal nerve fibre layer (RNFL) defects in patients with Stargardt disease by using spectral-domain optical coherence tomography (SD-OCT).

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This paper reports on a pilot study performed in the period June-October 1999 in the Rome municipal area by using five biomonitoring mini-stations and ozone passive samplers with a new nitrite based design. The carboxylate group was introduced at paclitaxel C-7 position to improve the drug water solubility without significantly changing the biological activity. To determine pharmacokinetics and plasma steady-state kinetics of metformin after oral or nasogastric administration in insulin-resistant (IR) ponies. Sex, stress, and mood disorders: at the intersection of adrenal and gonadal hormones. Acquired esophagotracheal fistula secondary to a foreign body in the esophagus.

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The isolation and structure of a sapogenin from Gua Zi Jin (Polygala japonica Houtt) In the majority of studies, there was a lack offollow-up and the inability to determine long-term outcomes of patients who received sodium profiling.

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Mesiodistal migration of the mandibular buccal teeth between ages 6 and 16. The cag-8 protein was localized in the cytosol and in granular bodies within the nucleus. Conducting parental and HCP follow-up for pediatric deaths reported to VAERS was resource intensive. Time to onset of action of vardenafil: a retrospective analysis of the pivotal trials for the orodispersible and film-coated tablet formulations.

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We found a significant increase in the expression, alteration in calpain II distribution and increased activity of this enzyme. Reduced lymphocyte activation in space: role of cell-substratum interactions. To further characterize target gene specificity of NFATc and NFATp, we generated deletion mutants as well as mutants swapping the C-terminal region of their DNA binding domains, and analyzed their DNA-binding specificity to different target sites.

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Studies on benzodiazepines and opioids administered alone and in combination in rhesus monkeys: ventilation and drug discrimination. Epigallocatechin gallate induced higher effects compared to quercetin on the membranes isolated from subjects with higher cardiovascular risk. In a 2002 cadaveric dissection course, a complex manner of rare variation was found in the abnormal venous system of the heart of an 88-year-old Japanese man who died of acute pneumonia. This technique is especially used in very severe deficiencies where the aim is to avoid the bedridden situation. Autografting for chronic granulocytic leukemia in transformation.

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The results from the bone organ cultures show that alendronate can enhance IL-6 production elicited by higher concentrations of the cytokine IL-1beta in bone, but that this effect on IL-6 does not prevent the inhibitory actions of alendronate on bone resorption. Pathological anatomy and histogenesis of the primary malignant lymphopathias. Endoscopy revealed a phytobezoar in a wind sock web, a special form of congenital duodenal atresia.

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It is important to appreciate differences between murine and human PDGF gene expression because PDGF is a key mitogen in the pathogenesis of fibrosis and mice are commonly employed as models for human disease. Group C included infants not in group R, with TSB levels of at least 12 mg/dL before 48 hours, 15 mg/dL before 72 hours, or at least 17 mg/dL after 72 hours. Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia. Investigation of severe back pain after epidural anesthesia should include consideration of infectious causes, such as vertebral osteomyelitis and discitis, which may not be causally related to the epidural catheterization itself. The Effect of Bariatric Surgery on Diabetic Retinopathy: Good, Bad, or Both?

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Serum separated and liver was excised and microsomal fraction was isolated for assaying cytochrome P450, NADPH Cyt P450 reductase and b(5). The reaction is ideally suited for structurally complex substrates and exhibits high levels of chemoselectivity (functional group tolerability), regioselectivity (coupling occurs exclusively at C-3 of indole or C-2 of pyrrole), stereoselectivity (substrate control), and practicality (amenable to scaleup). The difference between areas was explained by differences in the combined professional and lay support and by the sex and age distributions. Effects of inhaled corticosteroids with different lung deposition on exhaled hydrogen peroxide in stable COPD patients.

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These data indicate that both the hypervolemia and the vasoconstrictor activity of PRA and/or catecholamines are present when hypertension develops in these patients. In this study, the authors prospectively evaluated 797 babies born between 1996 and 1998 as part of a limited targeted ultrasound screening program. Epithelial Cell Packing Induces Distinct Modes of Cell Extrusions. to the level of range of sampling), but also a spatially restricted clade (e.g. Photodynamic therapy (PDT) efficacy appears to be enhanced in the presence of an intact immune system and PDT has been shown to augment anti-tumor immunity.

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Small renal mass with contralateral large renal mass: remove large renal mass first in staged fashion. Epidermal growth factor receptor/human epidermal growth factor receptor 1 and ligand expression is common in biliary cancers (BILI) and may be associated with worse outcome. One hundred adult patients of either sex were randomly assigned into two groups of fifty each.

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All women undergoing a primary cesarean delivery at a Network center during a 2-year time span were prospectively ascertained. In this study, we show that in AM and PBMC from IkappaB-alpha knockout/IkappaB-beta knockin mice, SP-A fails to inhibit LPS-induced TNF-alpha production and p65 nuclear translocation, confirming a critical role for IkappaB-alpha in SP-A-mediated LPS inhibition.

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Efferent projections of the torus semicircularis to the medulla of the tadpole, Rana catesbeiana. Esherichia coli endotoxin was administered intravenously to 7 Holstein adult cows, to evaluate the effect of endotoxin on acid-base balance. An extremely dense fibrosis is responsible for the main complications of alveolar echinococcosis (AE), a severe parasitic disease due to the development in the liver of a larval form of the cestode Echinococcus multilocularis.

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The use of pro-drug-activating genes is a possible approach for cancer gene therapy. Regulation of prostaglandin E2 synthesis by cytokines was further examined at the m-RNA level of cyclooxygenase-2.

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Pharmacological experiments suggested that calcium- and diacylglycerol- (DAG) associated pathways, but not cAMP, participate in the hypophysiotropic activity of H3. The volume of reparative tissue remained at an almost constant level after implantation. A clear P3a was elicited during deep sedation by those deviants, which were task-relevant during the awake state. Clinical data were obtained at baseline and at 1 and 2 year follow-up. The two-dimensional finite element method was applied to calculate the temperature and thermal-stress fields of these two films.

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To determine if the absence of GLP-2 was a general feature of stomach proglucagons we isolated and characterized proglucagon cDNAs from the stomach and the pancreas of the dog, a mammal that expresses the proglucagon gene in the stomach. In addition to metabolic acidosis, acute renal failure and neurologic disease can occur in some of the intoxications.

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Birds are continuously confronted by a large number of stressors, including pathogens. Comparison of the activities of prostacyclin and its stable analogs on the platelet aggregation and cardiovascular systems. Awareness about worker safety in nighttime construction has been a major concern because it is believed that nighttime construction creates hazardous work conditions. Terminal nerve distribution to the urethra and bladder neck: considerations in the management of stress urinary incontinence. In group I patients no significant change was induced by nifedipine in GCVF or in ARCR either at rest or at peak exercise.

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The implications of the findings were discussed and suggestions made regarding the disposal of mentally ill offenders for future consideration. Can a delayed malaria relapse occur without detectable reinfection after 19 or 25 years? An analysis was undertaken of physician visits, cardiac-related disease co-morbidities and hospitalisation.

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Allografts and autografts of the central ear arteries of rabbits, 0.5 mm in diameter and 10 mm in length, were transplanted in rabbit ears and subsequently enclosed with transparent plastic discs on each surface of the ear in place of the reflected skin. PKD1, PKD2, and their substrate Kidins220 regulate neurotensin secretion in the BON human endocrine cell line. Need for more evolutionary and developmental perspective on basic emotional mechanisms. Meanwhile, there are also some rising concerns of the potential side effects and drug-drug interactions of this plant. Adoption of these screening systems also can be hampered by lack of internationally coordinated and accepted validation protocols.

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Are the contents of treatment outcomes in fibromyalgia trials represented in the International Classification Of Functioning, Disability, and Health? A probably congenital icterus in a newborn with protracted hepatic immaturity In this short communication data from the United States, Canada and Israel is presented with a call for a professional response to this public health challenge.

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True aneurysm of the inferior gluteal artery: case report and review of the literature. Diagnostic evaluation of fine needle aspiration cytology in the management of palpable breast lesions. GW280430A degradation was primarily through ester hydrolysis and followed first-order kinetics in aqueous solutions. Estimation of contact tympanic membrane temperature with a noncontact infrared thermometer.

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A near-haploid bone marrow karyotype in systemic mast cell disease: is it characteristic of the disease or an incidental finding? An Efficient Light-Inducible P53 Expression System for Inhibiting Proliferation of Bladder Cancer Cell. The isolation and characterization of an alkylating-agent-sensitive yeast mutant, ngs1. The history and development of the Department of The History of Science and Medicine of Yale University.

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Synchrotron X-ray studies of the keel of the short-spined sea urchin Lytechinus variegatus: absorption microtomography (microCT) and small beam diffraction mapping. The program enrolled 147 participants and was delivered on four different occasions. The properties of the plant that control biomass allocation are discussed on the basis of these findings.

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MAD-related proteins are a recently identified family of intracellular proteins that are thought to be essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily. The ADAMTS family has a role in extracellular matrix degradation and turn over and has previously been involved in various human biological processes, including connective tissue structure, cancer, coagulation, arthritis, angiogenesis and cell migration.

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Neutron spectra from the capture of negative pions in carbon, oxygen and nitrogen. The gravitropical behaviour of apices from hairy root cultures of this clone has been compared with root tips from normal seedlings. Esophageal replacement for benign disease can be accomplished with a low mortality rate and a marked improvement in alimentation. Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking.

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Likewise, markers associated with a successful colonization (bacteriocin genes and genomic islands) and genome plasticity (phages and clustered regularly interspaced short palindromic repeats) were investigated for lifestyle specific genetic features. In conclusion, any kind of insect may provide valuable sources of LC-PUFA.

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Polymorphism of TaqI of ET-1 gene is correlated with the pathogenesis of cirrhotic portal hypertension. Evidence needed for policy decisions: adherence interventions and Medicare Part D. Physiological stress associated with toluene exposure in batch cultures of Pseudomonas putida 54G was investigated. Yet, although T-ALL infiltration and progression are independent of the stroma, accumulated disease burden leads to rapid, selective remodelling of the endosteal space, resulting in a complete loss of mature osteoblastic cells while perivascular cells are maintained. Little information is available on the optimum technique for soldering high-palladium alloys, which have gained considerable popularity for prosthodontic applications.

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Induction of multiple PCR-SSCPE mobility shifts in p53 exons in cultures of normal human urothelium exposed to low-dose gamma-radiation. These results shed light on the poorly understood cellular mechanism through which elevated seawater temperature causes the release of symbiotic algae from symbiotic cnidarians, a detrimental process known as coral (cnidarian) bleaching.

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Comparison of carbohydrate metabolism in normal and neoplastic liver enzyme studies. The important key technologies required for the successful biological conversion of lignocellulosic biomass to ethanol have been extensively reviewed. These properties of individuals are embedded within (d) social and (e) environmental determinants of health.

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Hepatocyte nuclear factor 6 (HNF6) is one of liver-enriched transcription factors. An appreciation of this connection is timely and important to alert readers to the possibilities of new disease mechanisms and new ways to diagnose and treat cancer. Based on the work on this series, a European network for IF could be an effective model for fulfilling the diagnostic and management needs, including intestinal transplantation. Methods of determination of specific and nonspecific cholinesterase in the blood microdrop It is suggested that the varying results obtained by different workers may be due to the differing characteristics of the anti-carcinoembryonic antigen serum used.

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L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. Of the TOCNs examined, that with a carboxyl content and aspect ratio of 1.2 mmol g(-1) and 120, respectively, was the most effective in reducing postprandial blood glucose, plasma insulin, GIP, and triglyceride concentrations.

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These results are not only important from an industrial point-of-view but also provide new evidences supporting the essential role of densification and consequently stress-generation as the main driving factor promoting enhanced etching rate following laser exposure. MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases. mRNA analysis showed the highest expression of Homer1a at 8h after SE onset, while immunohistochemistry demonstrated that Homer1a protein expression was significantly increased in hippocampus, amygdala and piriform and entorhinal cortices at 24h after SE onset when compared to control animals. In this model, short RNA hairpins with stems homologous to the acceptor arm of present day tRNAs were extended with regions homologous to TPsiC and anticodon arms. Synthetic, structural, and mechanistic studies on the oxidative addition of aromatic chlorides to a palladium (N-heterocyclic carbene) complex: relevance to catalytic amination.

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Post-call cognitive function and satisfaction in medical students on different call schedules: a prospective observational pilot study. A prospective study of hypertension first appearing during and after saphenous vein bypass coronary surgery was performed in 28 patients to examine the incidence, hemodynamics and mechanism of this problem. These findings show that the memory of tutor syllables survives auditory perturbations during the period when it is normally recalled and that zebra finches can use the memory well after the normal period of song development. Nine MFS families (17 patients) were analyzed with single strand conformation polymorphism (SSCP) and sequencing. Urine toxicology samples in cocaine treatment trials: how many need to be tested?

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Conservative surgical treatment of low-grade urothelial carcinoma in the renal allograft recipient: a case report. Acupuncture increases neuropeptide Y expression in hippocampus of maternally-separated rats. To identify the specific changes required to become a medical home, the authors reviewed literature and sought the opinions of two multi-stakeholder groups.

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Results show that aging influences more biochemical factors in pigs than in calves, and in nursing sows variations observed between day 5 and 15 after farrowing are of greater amplitude than between day 15 and 25. To form complex organs, these sheets are folded and reshaped by cell-shape changes. The preliminary findings of the study are supportive of these hypotheses.