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This phase II study was designed to evaluate the efficacy and toxicity of 3-h interval sequential methotrexate (MTX) and 5-fluorouracil (5-FU) with leucovorin (LV) rescue in the treatment of patients with metastatic colorectal cancer. Magnetite nanoparticles are expected to be applied in the medical field because of their biocompatibility and high saturated magnetization. Dopamine D2 receptors (D2-Rs) in the central nervous system are involved in the control of locomotion, cognition, emotion and neuroendocrine secretion.

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In line with the reduced levels of VEGF-A and other angiogenic factors, and increased levels of angiogenesis inhibitors, capillary-to-muscle fiber ratio was lower in diabetic mice compared to healthy controls. A culture system was developed in which human peripheral blood mononuclear cells depleted of monocytes did not proliferate in response to the lectin mitogen phytohemagglutinin (PHA). Adverse effects of the antiangiogenic agent angiostatin on the healing of experimental colonic anastomoses.

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The effect of BQH was similar to that of Enapril, but superior to that of Enapril in reducing BUN and SCr. Mutagenicity of para-substituted alpha-methylstyrene oxide derivatives with Salmonella. Oxidative stress has been frequently implicated in the initiation and promotion phases of carcinogenesis. Orlistat treatment results in a dose-dependent reduction in body weight in obese subjects and is well tolerated. Pellagroid syndrome with pseudo-myopathic signs cured with pyridoxine

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Monoclonal antibodies have been used as a therapeutic option for patients with lymphoma for less than 5 years, but they have already changed our perception of how to treat these patients. In contrast, sequence conservation, phylogenetic analysis, and physiology suggest that both Nar and Nap were acquired by horizontal gene transfer.

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A secondary objective was to compare the clinical characteristics of children with and without rotavirus acute gastro-enteritis (RV AGE). CD44 associates with EGFR and erbB2 in metastasizing mammary carcinoma cells. Introduction of specific amino acid substitutions surrounding residue 400 into T251-708 prevented the fragment from cooperating with Ras. Contribution to the in-vitro action of a thiapyrone derivative on the tributyrin and acetylcholine splitting enzymes in rat blood

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A He-Ne laser beam directed at the surface of bone specimen produces light scattering which generates the speckle. GTP-binding proteins are involved in cell proliferation, development, signal transduction, protein elongation, etc.

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Positive phototaxis was analyzed in the unicellular photosynthetic flagellate, Euglena gracilis, under the conditions of microgravity during a parabolic rocket flight (TEXUS experiment). In this review, we will mainly describe the role of integrins in regulating cell motility and discuss some new paradigms in integrin biology that may impact upon nephrology with respect to renal development and renal functions during both physiological and pathological events.

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A dynamic role of the medial temporal lobe during retrieval of declarative memory in man. Furthermore, at least 20 h of preincubation with the two cytokines was needed for optimal protection. Multiple peptides and peptide forms can be detected simultaneously and with great sensitivity in tissue extracts or partially purified samples.

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Analysis scripts and brief usage information are freely available upon request. One year after delivery the patient was still amenorrhoeic and had galactorrhoea with hyperprolactinaemia indicating that she probably had a small pituitary adenoma which was incompletely removed during neurosurgery. In vitro sensitivity of Neisseria gonorrhoeae to antibiotics, 1960 status Thyroid cancer 1 (TC-1) is a 106-residue naturally disordered protein that has been found to associate with thyroid, gastric, and breast cancers. To evaluate the neuropsychological and psychiatric sequelae of unilateral posterior pallidotomy for treatment of PD.

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The presence of the channel in this system is crucial for the high-frequency synaptic transmission of auditory signals. The influential factors of preparation conditions included molecular weight of chitosan, concentration of chitosan solution, concentration of acetic acid, loading of vitamin D2 were discussed.

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Nodular lymphocyte predominant Hodgkin lymphoma: diagnostic pearls and pitfalls. In this study, we observed the role of 2-deoxy-D-glucose (2DG) on inflammation of chondrocytes.

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The findings of this study do suggest that the culturally adapted OHIP-14 version may be a good research instrument to be considered for use in measuring the impact of oral problems on the quality of life in Czech population. Postoperative remission status was associated with a significant decrease in values for all tumor sites. The upstream mitogen-activated protein kinase kinase kinase (MAPKKK, or MEKK), BCK1, is an essential component in this pathway for maintaining cell-wall integrity and preventing fungal cell lysis. This TF can also trigger Pb activity in response to 3-methylbenzoate (3MBz), but with lower efficiency. Data were drawn from the parent study, a cross-sectional study investigating HRQOL in 86 Chinese- and 71 Korean-American BCS in Southern California.

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Comparison of disc diffusion, Etest and agar dilution for susceptibility testing of colistin against Enterobacteriaceae. In this review we will discuss the mechanisms of action and preclinical/clinical data for several of these compounds that have the potential to play an important role in the management of thyroid cancer in the future.

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On the diagnositc significance of puncture of the lymphatic nodes in tuberculosis Metabolite identification in the complex NMR spectra of biological samples is a challenging task due to significant spectral overlap and limited signal-to-noise. Elevated plasmatic adenosine deaminase activity, impaired platelet 14C-adenosine incorporation and hemostatic dysfunction in chronic myeloid leukemia. Safety and efficacy of the supraclavicular approach to thoracic outlet decompression. Are folliculo-stellate cells in the anterior pituitary gland supportive cells or organ-specific stem cells?

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Six surface-exposed positions in sTF, residues known to contribute to the sTF-FVIIa interaction, were selected for cysteine mutation and site-directed labeling with spin and fluorescent probes. Human immunodeficiency virus (HIV) prevalence rates among Black Americans are also disproportionately high. The new fermentation technology converting xylose to ethanol needs also to be developed to make the overall conversion process more cost-effective. Stenting for intracranial aneurysms: how to paint oneself into the proverbial corner.

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The fixed-ratio observing requirements appeared to facilitate control by stimuli serving an instructional function. Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300. Contrary to previous studies and because of the very rapid signal acquisition by this technique, we can obtain structural information about true reaction intermediates of transcription initiation.

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To characterize nuclei from pancreatic adenocarcinoma and nonneoplastic pancreatic tissue by digital karyometry, demonstrating specific nuclear signatures for each of them. Our findings suggest that cyclin D3 primes myoblasts for differentiation by enhancing muscle specific gene expression and cell cycle exit. An unusual mechanism of bacterial gene expression revealed for the RNase P protein of Thermus strains. In order to observe the protein compositions of soluble extracts of P.

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The grafted skin was lighter in Fitzpatrick Skin Type III, followed by Type IV and then Type V. The purpose of the study was to examine the variability in presentation and outcome of individuals presenting with acquired toxoplasmosis retinitis in the setting of an outbreak of the disease. After the PED encounter, mothers were asked about demographics, health problems, insurance status, social support, food and housing security, and 3 questions from the EPDS. Central Factors Contribute to Knee Extensor Strength Loss after 2000-m Rowing in Elite Male and Female Rowers. The results suggest that an ordered pattern of metabolic and morphologic changes occurs during neoplastic cell transformation.

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Sodium chloride regulates Extracellular Regulated Kinase 1/2 in different tumor cell lines. Cardiac troponin I (cTnI), a sensitive and specific marker of myocardial cell injury, is useful in diagnosing and assessing prognosis in acute coronary syndromes.

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Two morbidly obese males weighing 159 kg and 184 kg underwent percutaneous nephrolithotomy (PCNL) for large, symptomatic renal stones. Diagnosis is made from accurate history taking, physical examination, and polysomnography. Finally, the recent literature supports percutaneous nephrolithotomy as a safe and effective treatment option for large renal calculi and staghorn calculi. Former pathological and electrophysiological studies clarified that the cavotricuspid isthmus is composed of distinct muscular bundles, which are responsible for the conduction of electrical activation.

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Introduction to the JPA special supplement on International Reference Samples for the Rorschach Comprehensive System. A scaffold-filter model for studying the chondrogenic differentiation of stem cells in vitro. Abdominal pain and rectal bleeding as a complication of biliary stent migration in a liver transplant recipient.

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Many questions about the impact of depression on heart disease remain unresolved. The result of this experiment is: A significant shortening of mitosis under 0 g simulation compared to 1 g controls. The 2D gel maps of PC supernatant proteins displayed many features of plasma protein maps.

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Enzyme activity was regenerated from complexes formed with the P6-P2 variant faster than with wild-type indicating that the rate of turnover of the complex was increased. The reliability of visual examination of de-fleshed bones was assessed for detection of postcranial metastatic disease in individuals known to have had cancer. A(2A)R expression was increased in macrophages, macrophage-derived chemokines were reduced in response to the A(2A)R agonist, and chemokines not expressed in macrophages did not respond to A(2A)R activation. The model compound investigated was a beta-cyclodextrin (beta-CD) derivative with a nicotinamide group attached to the secondary face of a beta-CD (Fig.

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The present case is the fifth, and only the second from this subcontinent. Ovarian carcinomas and some brain tumors express the high-affinity folate receptor (FR).

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In the ICF experiments, the particles of interest, such as D(3)He-protons, have ranges of order of the detector thickness. Clinicians should consider the recommendations ofnonpharmacological measures to assist patients at risk for experiencing the culminating event of this destructive disease. To assess the main determinants of oral contraceptive (OC) use among teenaged girls in southeastern Hungary. Two piglets which had a history of anorexia and weakness were examined pre and postmortem.

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Cardiac protection and antihypertensive therapy: facts and theories Current evidence suggests that obstructive sleep apnea-hypopnea syndrome (OSAHS) is an independent risk factor for systemic hypertension. Can local Erythropoietin administration enhance bone regeneration in osteonecrosis of femoral head? Increasing diversity and complexity of older adult healthcare needs signals a need to reconceptualize perceptions of successful aging. Treatment and evacuation of asphyxic forms of poliomyelitis in Algeria

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Aerobic biotransformation of 2,4-dinitroanisole in soil and soil Bacillus sp. A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. In periods of stratification the soluble Mn(II) builds up to concentrations of 20 micromoles or more in the bottom waters.

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Our results raise questions regarding the validity of the assessment of the behavioural toxicity of SSRIs based on CFF measurements without ample control for pupil size, especially when these concern acute measurements. In this essay, I explore the theatrical dimensions of psychotherapy. One subtype designated circulating microvesicles (MVs) provides a novel form of intercellular communication and recent work suggested the release and uptake of morphogens in vesicles by Drosophila cells. Sensitivity and resistance of type 1 polioviruses to an inhibitor in certain horse sera.

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Due to the inherent sequence redundancy between RTE loci, assigning piRNA targeting to specific loci is problematic. Retrograde left cardioangiography as a test of valvular competence. Intervention strategies applied include environmental management through source reduction (drainage of canals, land levelling or by filling ditches with soil), habitat manipulation (by provision of shading from arrow root plant), application of Bacillus thuringiensis var israelensis (Bti) and the use of predatory fish, Gambusia affinis. We present model calculations, performed within a modified ion-specific double-layer theory, that demonstrate the large effect of including these ionic dispersion potentials. To assess the performance and to provide more detailed insight into characteristics and limitations of devices for automatic dose control (ADC) in CT.

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The authors present a generalized overview of phaeohyphomycosis as well as a more specific breakdown and case study involving subcutaneous phaeohyphomycosis. Social capital and health: civic engagement, community size, and recall of health messages. Immunofluorescence was used to determine accessibility of epitope-tagged SUR1 in intact and permeabilized cells. Improvements in quantum chemical methods have led to increased applications to biological problems, including the development of potential energy functions for molecular mechanics and modeling of the reactive chemistry in enzyme active sites, with particularly interesting progress being made for metal-containing systems.

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The results make it helpful to elucidate the molecular mechanism of potent cytotoxicities of lidamycin to tumor cells. Associations between functional ability, social contacts, and emotional loneliness and social loneliness were also assessed. We also show that CD9 function-blocking antibody inhibits parietal endoderm migration in an embryoid body outgrowth assay. To provide appropriate diagnosis and successful treatment, the cooperative work of many faculties is essential. We (i) describe our method and the data-processing algorithm, (ii) demonstrate our approach in model and in vivo experiments, and (iii) discuss the limitations.

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The aim of the study was to compare Acute Physiology and Chronic Health Evaluation II score and C-reactive protein as a clinical index and computed tomography-based severity index (CTSI) in predicting the course of acute pancreatitis. Until recently, this had been extremely challenging to achieve as nontransformed human cells are significantly refractory to both these processes. Over the years, however, new forms of RNA were discovered, such as microRNA (miRNA) and large intergenic noncoding RNA, and the range of RNA function was extended, miRNA constitutes a large family of small, approximately 20-nucleotide-long, noncoding RNA which controls the expression of target genes at the posttranscriptional level. From 1987 to 2003, a consecutive series of 34 congenital scoliosis or kyphoscoliosis due to thoracolumbar hemivertebrae were managed by hemivertebra resection using a combined posterior and anterior approach and short anterior and posterior convex fusion in the same day/same anesthesia. In Arabidopsis thaliana ecotypes Columbia and Landsberg erecta, colonization of the rhizosphere by P.

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This paper contributes in two ways to the aims of this special issue on abstraction. MANY NHS trusts are failing to meet the basic requirements for promoting race equality, a review by the Healthcare Commission has found. Second-order schedules of token reinforcement: comparisons of performance under fixed-ratio and variable-ratio exchange schedules.

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Application of fad theory to copycat crimes: quantitative data following the Columbine massacre. Knowledge about inhaler use among the chronic asthma patients in selected hospitals. First, the system is used to assay the response of HeLa cells to the effects of the surfactant Tween, which reduces the impedance of the trapped cells in a concentration dependent way and is interpreted as gradual lysis of the cell membrane.

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It is concluded that HRQL is largely related to factors which are inherent to the patient and the amputation. A careful study of the crystal structures of commonly occurring amino acids, and their racemates and complexes reveals that each hydrogen bond connecting the alpha-amino and the alpha-carboxylate groups and its symmetry equivalents generally give rise to an infinite head-to-tail sequence in which the two groups are periodically brought into close proximity. The study of oocyte and preimplantation embryo biology has been regarded with great curiosity throughout scientific history, but it is not until the development of robust methods for in vitro observation and manipulation of animal gametes that developmental biology has flourished as a discipline. The physical-chemical properties of the fabricated polymer hydrogel can be adjusted by CaCO3 whisker content, such as pore size, porosity, water content of materials and surface topography. An analysis for interaction according to the method of Berenbaum indicates a moderate synergism at the IC(50), which gets stronger with increasing ICs and reaches the highest level at the IC(99).