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Orlica (Orlistat)

Orlica works by inhibiting lipases in the gastrointestinal tract such that fat absorption is partially blocked. Orlica is FDA approved for up to 2 years of continuous use, and it has been shown to be effective for significant and sustainable weight loss, as well as for improving lipid levels, enhancing glucose metabolism, and lowering blood pressure. The discontinuation rate of Orlica is relatively high because of gastrointestinal side effects related to fat malabsorption and roughly equates to 33% in various studies. In one study, lifestyle intervention and Orlica treatment for 4 years delayed the development of type 2 diabetes in obese subjects by 37%, a finding perhaps attributable, in part, to the weight loss achieved. Orlica is now available in half-strength (60 mg per dose) over-the-counter under the brand name Alli.

Other names for this medication:
Orlistat, Cobese, Ishape, Lipocut, Lipophage, Obelit, Obezita, Oristal, Orlica, Reeshape, Vyfat, Xenical,

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A pressure of 100 MPa increased the CEP activity, whereas 200 MPa had no effect. Many teenagers are driving inferior vehicles in terms of crashworthiness and crash avoidance.

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Big endothelin-1 but not endothelin-1 is present in the smooth muscle stroma of the prostate gland of the rat. Gaucher disease: functional expression of the normal glucocerebrosidase and Gaucher T1366G and G1604A alleles in Baculovirus-transfected Spodoptera frugiperda cells.

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Combining immunocytochemistry and ultrastructural investigations, we show that glomeruli in Xenopus laevis tadpoles lack any cellular borders. Relaxation and stress management in the treatment of essential hypertension. Inhibition of the synthesis of desoxyribonucleic acid of Trypanosoma mega by urea in low concentration Total knee arthroplasty in severe valgus deformity: interest of combining a lateral approach with a tibial tubercle osteotomy. A 1:1 phenotypic distribution was observed, and a locus (Suppressor of superoxide production, Susp) controlling this phenotype was mapped to Chromosome 3 near D3Mit241 at 33.1 cM.

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In particular, we derive inversion formulas for this problem that are based on the functional singular-value decomposition of the linearized forward-scattering operator in the slab, cylindrical, and spherical geometries. Mediator-RNA polymerase II complex isolated from the mutant yeast strain was temperature sensitive for transcriptional activation in a reconstituted in vitro system due to a defect in initiation complex formation. Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2. Polymer-bound carbonic anhydrides in N-acylation of 7-aminocephalosporanic acid.

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Metastatic lymph node targeted chemosensitivity test for gastric cancer. The cells started to accumulate at the site within 1 hr and the number of eosinophils at the site reached its peak at 8 hr after the injection of the extract. Peptide recognition by PDZ and other protein interaction domains represents one of the best-studied classes of specific protein associations.

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Zooming-in on the proteome: very narrow-range immobilised pH gradients reveal more protein species and isoforms. None of these substances influenced significantly insulin release from the perfused pancreas. The program features 4 CORE components: (a) an annual 6-week summer school program, (b) a teacher consultation and student mentoring program, (c) child social skills groups, and (d) parent education and skills-training groups, all delivered in tandem with a FLEX family support program individually tailored to address the unique needs of families. Consequently, atrioventricular node-His bundle conduction and accessory pathway conduction can be continuously monitored to avoid inadvertent injury to the atrioventricular node-His bundle system. Cross sectional study of performance indicators for English Primary Care Trusts: testing construct validity and identifying explanatory variables.

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In general, elbow and shoulder loads were the greatest in the fastball and least in the change-up. Coherent motion, magnocellular sensitivity and the causation of dyslexia.

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Effects of prenatal androgenization and lactation on adipose tissue metabolism in finishing single-calf heifers. coli K-12 is grown on acetate or oleate as the sole carbon source. Schedule-dependent potentiation of chemotherapeutic drugs by the bioreductive compounds NLCQ-1 and tirapazamine against EMT6 tumors in mice.

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Conversion of DGLA to PGs by a lung cyclo-oxygenase appears to mediate the response, since it was blocked by indomethacin and dose not occur with injection of nonprecursor long-chain fatty acids. Fetal mortality in maternity hospitals of Nancy (1952-1956): etiological study Quantification of pulmonary emphysema from lung computed tomography images.

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Stabilographic data from either the forelimbs or hindlimbs may be useful for detecting and quantifying deficiencies in postural balance in ataxic horses. A portion of the primary known feeding area of the endangered western gray whale (Eschrichtius robustus) is located adjacent to the seismic block. Although there has been a significant increase in the prevalence of fistulae in the United States over the last several years, many of these patients require central venous catheters during the fistula maturation process. A multiplex RT-PCR assay based on GeXP system was developed in order to detect simultaneously human enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) and other coxsackieviruses (CVA4, 5, 9 and 10, CVB1, 3 and 5).

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Evaluation of the addition of bupivacaine to intrathecal morphine and fentanyl for postoperative pain management in laparascopic liver resection. Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling. We evaluated hyperintensities in the deep nuclei of the brain in 6 patients with normal renal function after intrathecal administration of a linear ionic GBCA, without other confounding intravenous GBCA administrations. Most of the patients maintained good correction and had good clinical results.

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Peritoneal carcinomatosis of colorectal cancer: cytoreductive surgery and hyperthermic intraperitoneal chemotherapy A hysterography and hysteroscopy confirmed the permeability of the cervix, which was lined by a well-vascularized longitudinally folded mucosa. In a group of 79 patients hospitalized on account of haemorrhage associated with portal hypertension the authors evaluate the diagnostic yield of radiological and sonographic methods. Gene expression profiling of wild type aging, and of strains with increased life spans, has provided some insight into potential mechanisms, and more can be expected in the future. PINCH-1 promotes activating phosphorylation of Src family kinase and ERK1/2.

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In only five cases, the patients had penicillin-sensitive pneumococcal infection. Varicosity of the pulmonary veins is a rare anomaly of the pulmonary vascular system. Tinea capitis is a superficial fungal infection of the scalp and hair of the head which is common in children aged between two and eleven years. Nuclear Overhauser effect in specifically deuterated macromolecules: NMR assay for unusual base pairing in transfer RNA.

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Patients with gastric adenocarcinomas containing high levels of VEGF-C expression have significantly reduced 5-year survival rates, and VEGF-C expression is an independent prognostic risk factor for death. SMS was sent to the patients to remind them of appointments at the SCC and to query their smoking state.

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Azithromycin monotherapy is equally as efficacious as other ATS-recommended regimens for treating hospitalized patients with mild-to-moderate community-acquired pneumonia. Pharyngeal and laryngeal local primary amyloidosis have relatively better prognosis than that of systemic amyloidosis.

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The rank order centroid method reduces the number of pairwise comparisons by placing the alternatives in order, although it has inherent weakness over the fuzzy method in expressing the degree of vagueness associated with assigning weights to criteria and alternatives. This strain was shown to produce proteolytic enzymes constitutively. Unregistered sex workers were interviewed in randomly selected establishments (official and clandestine bars, brothels and nightclubs), and blood, endocervical and vaginal samples were collected for laboratory diagnosis. Its performance under conditions that may occur during surveys in resource-poor countries is however, unknown. Assessing flow limitation in patients with stable coronary artery disease.

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Using exhalation breath-holds rather than inhalation breath-holds and delaying irradiation until after the first 10s of breath-holding may be advantageous for irradiation of abdominal tumors. A drop in sea level and climatic change are most frequently invoked to explain mass extinctions, but new theories of collisions with extraterrestrial bodies are gaining favor. Osteoblastic cells also signal indirectly to bone-resorbing osteoclasts via the secretion of RANKL. The cystic structure was initially diagnosed using ultrasonography, and its complete extent (8cm x 6.5cm x 4cm) was evident after magnetic resonance imaging.

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In contrast to the necrotic tissue, all cell types of the reparative tissue labeled strongly positive for VEGF. The heterogeneous distribution of enhancement determinants may provide a valence mechanism contributing to a multiple increase of infection enhancement in macrophages. In this work, we aim to assess the absolute values of CSS at different temperatures. Corticotropin-releasing factor-immunoreactive neurons of the paraventricular nucleus become vasopressin positive after adrenalectomy.

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The results suggest that heating the testis causes early membrane damage (TNS) to the late pachytene primary spermatocytes with the reduction of S-S bonds to SH (mercurochrome). It is suggested that the UV radiation, and shock and plasma phenomena which accompanied the hypervelocity impacts of solid bodies (meteorites and comets) onto the surface of the young Earth may have contributed to the synthesis of prebiotic organic molecules in the primitive atmosphere in a larger amount than was thought previously. In the laboratory rabbit, Oryctolagus cuniculus, these effects result in myxomatosis, a fatal condition characterized by skin lesions and systemic immunosuppression. Distribution of intravenously injected colloidal radioactive iron in iron proteins of the normal rabbit and of rabbits with turpentine abscess and diphtheria toxicosis.

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Viral RNA replication complexes from infected cells were also associated with ER-like membranes. The present study suggests that SOD1 may contribute to the early activation of the Akt cell survival signaling pathway and may attenuate subsequent DNA damage after transient FCI. Neighborhood characteristics and mental health: the relevance for mothers of infants in deprived English neighborhoods.

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More extensive health services at sites of the Baltimore NEP appear to be warranted, with particular attention paid to effectiveness for frequent exchangers. We thus conclude that betanodavirus B2 is a dsRNA binding protein that sequesters and protects both long and short dsRNAs to protect betanodavirus from cellular RNA interference.

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Remote observations on children infected with tuberculosis at an early age Urinary tract infection, hyperuricemia, septicemia, transitory abdominal pain, cerebral accident Saposin (Sap) D is an endolysosomal protein that, together with three other similar proteins, Sap A, Sap B and Sap C, is involved in the degradation of sphingolipids and, possibly, in the solubilization and transport of gangliosides.

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First, PWA from intra-arterial (brachial) and non-invasive finger pressure recordings was compared. Cellular and humoral immunological characteristics of chronic pyelonephritis Successful expression of a selenomethionyl protein under control of the temperature-sensitive lambda repressor requires higher than normal temperature. The relatively recent discovery that neuronal dendrites contain active conductances has revolutionized our view of information processing in neurons. This study assessed the cost-effectiveness of cervix and breast cancer screening in a public hospital emergency room.

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Lithotripter shock waves (SWs) generated in non-degassed water at 0.5 and 2 Hz pulse repetition frequency (PRF) were characterized using a fiber-optic hydrophone. Treatment of the fibroblasts with either of the inhibitors led to a marked increase in residual MK enzyme activity, which was largely attributable to increased MVK gene transcription. In a period of 4 years, 90 patients were included in this study.

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Immunological aspects of 40 northern Nigerian children with nephrotic syndrome of recent onset are reported. Craniofacial surgeons with various experience levels were able to accurately diagnose single-sutural synostosis by physical examination alone. The values of the various investigations, both audiometric and phonometric, carried out made it possible to demonstrate a significant exposure and a temporary increase in the threshold, above the frequency of 6000 Hz.

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Follicle formation in the canine ovary after autografting to a peripheral site. Contribution of organic cation transporter 3 to cisplatin cytotoxicity in human cervical cancer cells. Rats were given IP injections of 110 mg streptozotocin (STZ)/kg. We conclude that the hypernatremic condition may weaken local defence against burn wound infection at the zone of stasis and may be a risk factor for burn wound sepsis.

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The effect of MHC class I gene transfection on the metastatic properties of B16BL6 melanoma cells was investigated. Changes of the human tongue in protein and vitamin depletion and repletion. High sensitivity of protoplasmic cortical astroglia to focal ischemia. In all the skin regions, characteristic morphological abnormalities (absent or abnormal lamellar granules and intercellular lamellae, lipid inclusions in the cornified cells) were expressed in the late second trimester of the fetal period. Fetal protection against continual exposure to bovine viral diarrhea virus following administration of a vaccine containing an inactivated bovine viral diarrhea virus fraction to cattle.

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The results of SDS-polyacrylamide gel electrophoresis and cross-linking experiments indicated that carcinoembryonic antigen is a dimer composed of two identical or closely similar noncovalently bound subunits, dissociating on heating in the presence of SDS. The goal of three-dimensional (3-D) conformal radiation is to increase the dose delivered to tumor while minimizing dose to surrounding normal brain.

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Use of hypothermia in bloodless heart surgery: experimental study Inhaled doses of 100 micrograms, 200 micrograms, and 400 micrograms of fenoterol with isoproterenol and placebo controls were administered in a randomized double-blind crossover regimen.

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Different immunoassays were used as screening methods for drug testing in the above-reported matrices or as unique analytical investigation tools when chromatographic techniques coupled to mass spectrometry were not commonly available. Rhino-orbital-cerebral mucormycosis (ROCM): a comprehensive case review. Bright light therapy to promote sleep in mothers of low-birth-weight infants: a pilot study. Decompressive laminectomy with excision of the OLF resulted in significant improvement in motor weakness and gait in 5 (2 excellent, 3 good) patients who had short duration and no hyperintense intramedullary lesion of spinal cord on MRI. The findings suggest a dose-response relationship for radiographic TF knee OA in floor layers with a significant amount of kneeling work and an increase of MRI-verified medial meniscal tears among workers with kneeling work.

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Associations between health risk behaviors and opposite-, same-, and both-sex sexual partners in representative samples of vermont and massachusetts high school students. Balloon angioplasty disrupts the protective endothelial lining of the arterial wall, rendering arteries susceptible to thrombosis and intimal thickening. HIV risk among Australian men travelling overseas: networks and context matter. Genome integrity is protected by Cds1 (Chk2), a checkpoint kinase that stabilizes arrested replication forks. The aim of this prospective study was to analyze the changes in cerebrospinal fluid (CSF) distribution after endoscopic third ventriculocisternostomy (ETV).

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Tooth-borne/hybrid distraction devices offer a new approach for intraoral DO and better control of the distracted bony segments. One mechanism by which this was accomplished was disruption of tumor angiogenesis. However, there is a lack of knowledge about the prevalence of (1) residual symptoms in general and (2) the individual residual symptoms in particular. The activity of major anti-oxidative enzymes and the generation of reactive oxidative species (ROS) were measured by chromatometry and fluorochromy.

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We examined the role of genetic and environmental factors for smoking initiation using an extended kinship design. The causes and outcomes of malnutrition are discussed, and the TwoCal HN Med Pass program, designed to overcome poor dietary intake, is described. In addition, it was found that insulin was not mitogenic for recently divided lymphocytes, but prevented these cells from entering the resting state. Relative concentrations of albumin and IgG in cerebrospinal fluid in health and in acute meningitis. Two experiments, involving 181 participants and using an actual object array, were conducted in the present study to examine two learning conditions: incidental and intentional.

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Morphine or bupivacaine in controlling postoperative pain in patients subjected to knee joint arthroscopy. The elevated collagen fraction present in failing hearts may be the cause of increased stiffness and loss of elasticity that is detected in patients with end-stage HF. We used a systematic evolution of ligands by exponential enrichment (SELEX) procedure to derive high affinity oligonucleotide ligands (aptamers) recognizing CD4.

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Retroperitoneoscopic living donor nephrectomy: experience of 425 cases at a single center. GATA6 and FOXA2 regulate Wnt6 expression during extraembryonic endoderm formation. Still-frame video image captures were made of 1-3 regions of interest per biopsy specimen, with subsequent image analysis of adipocyte spatial characteristics performed via a user-written MATLAB routine.

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Significance of effectiveness of combined insulin-orinase treatment in maturity-onset diabetes. Last, although not considered in the present review, functional MR imaging provides the potential to evaluate, in a noninvasive fashion, the norvasc drug action of gabapentin role played by the basal ganglia in motor control and in cognition in normal individuals as well as in PD. Computational study of iron(II) systems containing ligands with nitrogen heterocyclic groups. Chemotherapy of TB consists of prevention of infection, also called primary chemoprophylaxis, when isoniazid 5 mg/kg is given to prevent infection in newborn infants of infectious mothers till mother is sputum smear positive (2-3months). Early life social factors such as family poverty could have detrimental impacts on the developing immune system, with potentially important consequences for later life health outcomes.

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Adenovirus stripping: a versatile quetiapine anxiety medication method to generate adenovirus vectors with new cell target specificity. In contrast, captive-raised frogs (Mantella aurantiaca) have no alkaloids detectable in skin extracts. High-speed and dense three-dimensional surface acquisition using defocused binary patterns for spatially isolated objects.

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Inclusion of chondroitin 4-sulfate or chondroitin 6-sulfate and to a lesser extent, heparin, in the T. A study on the occupational mortality in three Swedish professions. A medical and engineering research center and a tosufloxacin renal dose augmentin university biomedical engineering department. A report is presented of a female patient who developed an extensive bladder carcinoma with severe hemorrhaging after many years of treatment with cyclophosphamide for multiple myeloma. Effects of positive end-expiratory pressure ventilation and extracorporeal ultrafiltration method in patients with refractory heart failure.