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Topirol (Topiramate)
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Topiramate

Topirol is a medication that works in the brain and is sometimes used in patients with bipolar disorder (also known as manic depression). It is approved for the treatment of seizures (epilepsy) in adults and children in combination with other anticonvulsants and for preventing migraine headaches in adults. Bipolar disorder involves episodes of depression and/or mania.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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In the present study we have shown that genetic or developmental factors resulting in a lesser number of D2--relative to D1--receptors is associated with repetitive jaw movements. However, an empirical demonstration of their practical benefits is warranted.

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The results demonstrate that acrylamide-induced inhibition of purified ADH activity is mediated through its specific interaction with -SH groups in the enzyme molecule. After 21 and 28 days the tissue was excised and showed: a) resorption areas of the dentine contained dentinoclasts and macrophages. Self-care behaviors and health indicators in adults with type 2 diabetes. However, when signals were separated in frequency by several critical bands, a decrement in dichotic performance, as compared with monaural performance, occurred only in the divided-attention condition.

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In addition, coalescent-based Bayesian species delimitation shows G. Sera from donors exposed to malaria were tested for their ability to block the transmission of isolates from Cameroonian Plasmodium falciparum gametocyte carriers. We evaluated these two polymorphisms of MTHFR in patients with small cell lung cancer (SCLC) and non-small cell lung cancer (NCSCL). Surgical approach for treatment of the primary tumor, adjuvant therapy and treatment of advanced disease (chemotherapy, hormonal manipulation and immunotherapy) are discussed. Mature hematopoietic cells, like all other terminally differentiated lineages, arise during ontogeny via a series of increasingly restricted intermediates.

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A drug set is carried to the each operating room by an anesthesiologist or a nurse and they write down administered drugs in the document after surgery. While GSR change was consistently observed in all instances, its duration persisted far longer than did seizure activity as measured by observed tonic-clonic movements. Treatment of cardiogenic shock in acute myocardial infarction and postoperative low cardiac output

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Sodium hypochlorite disinfection on effluent of MBR in municipal wastewater treatment process The presence or absence of Tarlov cysts at the level of the sacral spine. Elucidation of the mechanisms of these associations has implications for prevention. The athymic nude rat: an animal experimental model to reveal novel aspects of innate immune responses? According to current knowledge, cancer treatments do not have transgenerational effects and do not increase the risk of cancer among the progeny.

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Application of homonuclear 3D NMR experiments and 1D analogs to study the conformation of sialyl Lewis(x) bound to E-selectin. After 96 h, the cerebral/apical ganglion and visceral ganglion are connected by a serotonergic process. The incidence of Staphylococcus pyogenes in normal human breast milk. The ability to rapidly and sensitively acquire tandem mass spectrometry data and perform peptide and protein identifications has become a commonly used proteomics analysis technique because of advances in both instrumentation and software.

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Certain drug-induced functional and immunological shifts are now believed to indicate the increase in the functional renal capacity and enhanced kidney resistance to inflammation. Multidetector-row computed tomography revealed an abnormal cavity in the left posterior aortic root. Comparative analysis of the structure of carbon materials relevant in combustion.

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After extracellular and intracellular equilibration, excess glycerol was removed by centrifugation. Mandibular movement by electromyography in unilateral cleft lip and palate patients

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The relationships between epidemiological information, BCG status (vaccination, BCG scars) and TST reactivity were assessed to compare TST sensitivity between children with and without BCG vaccination and between those with and without a BCG scar. A follow-up: high level of dioxin contamination in Vietnamese from agent orange, three decades after the end of spraying. A SAS program for calculating cumulative incidence of events (with confidence limits) and number at risk at specified time intervals with partially censored data. Intensity-modulated radiation therapy achieves better local control compared to three-dimensional conformal radiation therapy for T4-stage nasopharyngeal carcinoma.

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Although the lipid-binding domain seems to be located in the C-terminal region of the enzyme, as with the mammalian counterpart, the membrane anchorage, which plays a key role in the enzyme regulation, is driven by two alpha-helices, which behave differently from one another. In addition, childhood growth in length/height is to a high degree dependent upon having an adequate protein intake. Efficiency of casein hydrolysate medium for the growth of poliomyelitis virus Amebiasis in the territories of the French Union, and its relation to amebiasis in France The morphologia feature of brain tissue was observed under microscopy and immunohistochemistry, image analyze technique was applied to detected the expression of Bcl-2 and Fas.

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Poliomyelitis immunization in infants in the presence of maternally transmitted antibody. MR images were evaluated with emphasis on signal intensities on T(2) weighted images, margin characteristics and lymph node metastasis, correlating these with pathological features. The results suggest that specific antigens other than proteases or pili are important in determining whether a B.

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The giant colonic diverticulum is a very rare clinical entity usually located in the sigmoid colon of elderly patients. Contrary to data reported in the literature, this study indicated that the incidence of hypoparathyroidism following laryngeal surgery, even in radical surgical approaches, proved to be closer to zero. The effect of HFE mutations on serum ferritin and transferrin saturation in the Jersey population.

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Judges assume that gruesome evidence can influence juror verdicts, but little is known about the manner in which the influence is manifested. Evolutionary-aware meta-analysis of the growing GWAS literature is one way to address this challenge and to advance from association to causation in the discovery of genotype-phenotype relationships. High plasma ionized calcium with normal PTH and total calcium levels in normal-function kidney transplant recipients. The acquired immunodeficiency syndrome and a trimethoprim-sulfamethoxazole adverse reaction. The sensitivity of Brucella abortus to pH and to certain weakly bactericidal solutions.

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In this study, we analyzed the mechanism of ARF-dependent apoptosis and demonstrated that ARF induces mitochondria-dependent apoptosis in p53 wild-type, ARF/p16-null cells. A 42-year-old woman is reported who presented with persistent right flank pain after an alleged assault with injury to the area 3 weeks previously. Physiologic-biochemical basis of acupuncture--electrotherapy of drug dependence These data suggest the presence of a stem cell defect which may progress to myelodysplasia or overt marrow failure in these patients.

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HIV status of partners of HIV positive pregnant women in different regions of Nigeria: matters arising. Similarly for female, Cervix Uteri cancer had the highest incidence rate (5.35) whereas stomach had the lowest (1.06). Activation of normal fibroblasts by lipopolysaccharide induced a transient production of chemokines, closely followed by induction of RelB expression. The influence of BrdU in vivo on cell cycling, DNA synthesis, spontaneous sister chromatid exchange (SCE) frequencies, and gene-mutation frequencies (6-TGr) was determined in freshly isolated cells from a subcutaneous granulation tissue. Thus, truncation of Env enhanced genetic stability as well as serum and mucosal antibody responses, suggesting the desirability of a similar modification in MVA-based candidate HIV vaccines.

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Helix-stabilizing effects of the pentapeptide KIFMK and its related peptides on the sodium channel inactivation gate peptides. High-resolution magnetic resonance imaging of the upper eyelid: correlation with the position of the skin crease in the upper eyelid. Lung cancers with CPFE show some unique clinical characteristics, and the distinct histological subtype may have therapeutic implication.

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In addition, patients underwent scheduled annual coronary angiography. Antenatal care is provided during pregnancy to save lives of mother and foetus. Ultrasound diagnosis of soft-tissue tumours in the hand and forearm.

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The CID is thus poised to undergo a facile conformational change as required for DNA binding. The intensive care unit (ICU) is where patients are given some of the most technologically advanced life-sustaining treatments, and where difficult decisions are made about the usefulness of such treatments. The intent is to support current practice or determine better practices and to reduce risk of decompression illness (DCI) in recreational divers. Prevalence of restless legs syndrome in chronic kidney disease: a systematic review and meta-analysis of observational studies. A comparison of the two structures reveals subtle but important conformational changes that aid in the stabilization of the Trp191 cationic radical in Compound I.

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Polymerase chain reaction and DNA sequencing were used to confirm the etiological agent. Enterohemolysin (EHly) produced by Escherichia coli shows hemolytic activity towards washed erythrocytes from different animal species on blood agar plates.

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The natural compound Microcin C (McC) is a Trojan horse inhibitor of aspartyl tRNA synthetases endowed with strong antibacterial properties, in which a heptapeptide moiety is responsible for active transport of the inhibitory metabolite part into the bacterial cell. These tRNA preparations were then hybridised with DNA isolated from phage phi 149. In vivo productivity of total lipids and fatty acids was analyzed to confirm the changes and effects of the inserted genes in E.

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Chloroquine compared with chloroquine and emetine combined in ameblic liver abscess. Overexpression of Ec-TRX in grouper spleen (GS) cells could promote the growth of GS cells and inhibit the replication of SGIV. These results indicate that an ASR residue can be safely recycled after a separation process, followed by washing at acidic pH.

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Tracking membrane and secretory immunoglobulin alpha heavy chain mRNA variation during B-cell differentiation by real-time quantitative polymerase chain reaction. All studies reporting independent and blinded comparisons of preoperative or operative factors with postoperative pulmonary complications were included. Age-related slowing of digit symbol substitution revisited: what do longitudinal age changes reflect? Gender differences in trunk, pelvis and lower limb kinematics during a single leg squat. Namely, labeled selenium sources (76)Se-MeSeCys and (77)Se-MSA(IV), at a single oral dose of 10 microg Se/kg body weight each, were administered simultaneously to rats that had been depleted of natural abundance selenium with a single isotope (78)Se.

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Determination of the tissue distributions and relative concentrations of the postsynaptic 43-kDa protein and the acetylcholine receptor in Torpedo. The purpose of the present study was a direct comparison of fixed-angle plate fixation (FAPF) and shoulder hemiarthroplasty (SHA) for complex fractures of the proximal humerus in the elderly. The purpose of this study was to define the incidence and characterization of cardiovascular cause of sudden death in the young.

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Despite repeated public commitments and availability of various forms of iron supplements, rates of anaemia in developing countries remain high. Evaluation of plication in the treatment of peritonitis and its aftermath of intestinal adhesions. The major dietary sources of lycopene for the human are tomatoes and tomato products. However, only a few nonreplicating molecules successfully induce strong mucosal immune reaction without the addition of adjuvants by oral administration. However, because patients with epidermal growth factor receptor mutant lung adenocarcinoma (associated with non-smokers) tend to receive TKI treatment, they might have fewer smoking-related SPMs.

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The aim of this study was to estimate the financial burden of in-patients costs for endometriosis treatment in Germany in 2006. The end result is an up- or down-regulated synthesis and/or activation of liver-enriched transcription factors that in turn regulate many target genes coding for resident or secreted acute phase proteins. Deceleration injury causing a left chylothorax associated with a left vocal cord paralysis.

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Central venous pressure (CVP) monitoring is essential to guide adequate resuscitation. MGP mRNA levels were elevated by 5.0-fold at 50 ng/ml TGF-beta 1 in E11 embryonic mouse lungs explanted for 4 days in serumless culture. Chlamydiae dissociate themselves from the endocytic pathway shortly after internalization by actively modifying the vacuole to become fusogenic with sphingomyelin-containing exocytic vesicles. With pregnenolone as substrate, the inhibition induced by 4-substituted imidazoles of the release of corticosterone and cortisol was more pronounced than that of aldosterone. The 1623 patients discharged from the Moffitt-Long medical service between July 1, 1995, and June 30, 1996.

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Assessment of the role of PAR-2 in bronchoconstriction, airway responsiveness and immune response after allergic challenge, in rabbits sensitized to Par j 1, the major allergen of Parietaria judaica pollen. Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody B72.3.

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Maximal aerobic capacity of Canadian schoolchildren: prediction based on age-related oxygen cost of running. First experiences show good acceptance by the team members, improvements in communication and documentation as well as substantial gains in content and handling of rehabilitation conferences. We have shown previously that the receptors are functionally desensitized, in a homologous manner, by distinct kinase-dependent mechanisms in which P2Y1 is regulated by protein kinase C (PKC) and P2Y12 by G protein-coupled receptor kinases. NFAT regulates CSF-1 gene transcription triggered by L-selectin crosslinking. For the first time the selective binding of the moenomycin sugar moiety to the enzyme has been demonstrated.

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The surgical logistics of staging, open and closed approach, anesthetic method, and reconstructive planning are considered in detail. A major source of glycoconjugate structural diversity arises from the possibility of forming different linkages between the same monosaccharide units. To examine glycoconjugates in the isthmic and ampullar regions of the uterine tube (oviduct) of horses during estrus, diestrus, and pregnancy. The subject of the detailed analysis was demographic data, clinical symptoms as well as subjective complaints, results of neurological examinations, the results of cerebrospinal fluid (CSF) parameters and results of serologic tests. There are differences in outcomes in blacks compared with whites with lymph node-negative (pN0) colorectal cancer.

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Granulomatous interstitial nephritis is an uncommon finding in a kidney biopsy. The results indicate that both the oral and injectable forms of amygdalin were substandard by US criteria for manufactured pharmaceutical products. DE-310 is composed of the topoisomerase-I inhibitor DX-8951 (exatecan) and carboxymethyldextran polyalcohol (CM-Dex-PA) carrier, which are covalently linked via peptidyl spacer (Gly-Gly-Phe-Gly).

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Clostridium acetobutylicum produces substantial amounts of butanol, and an engineered cellulolytic strain of the bacterium would be an attractive candidate for biofuel production using consolidated bioprocessing. During apoptosis, Bid is cleaved (cBid) and translocates to the MOM, where it activates Bax.

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This paper describes gross and histopathological findings in four out of 20 rabbits aged 14 weeks, experimentally infected with one of two German field isolates of RHD virus. Staphylokinase mutants could have a better benefit/cost ratio than other thrombolytic agents. In addition, the intracellular and secreted IgG from an NS0 producer cell line were isolated, and their glycoform profiles were displayed using GlycoVis for comparison. Previous studies have shown mixed results on the cost-effectiveness of first-line cetuximab combined with FOLFIRI (5-Fluorouracil, leucovorin, irinotecan). The monophyletic nature of these bacteria in terrestrial environments has facilitated molecular biological approaches in studying their ecology, and progress in this field has been rapid.

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This study aimed to evaluate PRL and GH secretion after metoclopramide and thyrotrophin-releasing hormone (TRH) infusion in infertile patients with minimal/mild endometriosis. Forty-two centres including 24 neurological, 13 medical and five geriatric departments participated in the register. We demonstrated that the transfection of the PCR products into mammalian cells resulted in specific depressions of exogenous (luciferase, green fluorescent protein and beta-galactosidase) and endogenous (annexin II) gene expressions.

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Cycle of activity in function of the period of nymphal moulting. Our knowledge of both macrophage physiology and the nature of tuberculous lesions in man and animals suggests that hypoxia is a major factor in inducing nonreplicating persistence (NRP) of tubercle bacilli. Functional expression of corticotropin-releasing hormone (CRH) receptor 1 in cultured rat microglia.

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There is histological evidence for an ischemic etiology of TMES of the hip. The rectum and rectosigmoid junction were the commonly affected sites. Clinical use of indices determined non-invasively from the radial and carotid pressure waveforms. The patient is alive and well without evidence of recurrence 16 months after second surgery. With EBUS, the delicate multilayer structure of the tracheobronchial wall can be analyzed.

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The results of this report indicate the potential of anastrozole as an alternative drug in azelastine eye drop review the adjuvant setting, although the mean follow-up time is so far only 47 months. Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2.

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Both male Zucker Fatty (mZF) and lower-fat-fed female Zucker diabetic fatty (LF-fZDF) rats are obese but remain normoglycemic. Influenza vaccination: healthcare workers attitude in three Middle East countries. This study discovered a signature plasma protein profile for patients with AAA and demonstrated that mass spectrometric based research for disease specific biomarker of AAA is feasible. Our results demonstrate that OPN regulates Stat1 protein degradation through the ubiquitin-proteasome pathway to alter interferon-gamma-dependent growth inhibition and p21 expression. Pattern of Pediatric Uveitis at a Tertiary zidovudine lamivudine abacavir generic Referral Institute in North India.

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We suggest that cycles of alcohol intoxication/withdrawal, which may initially activate NF-kappaB, when repeated over years downregulate RELA expression and NF-kappaB and p50 homodimer DNA-binding. The limitations of methods of assessing bone mineral density (BMD) are highlighted and specific influential factors, which affect peak bone mass achievement and therefore skeletal health in later life, are evaluated. These areas fit best to the human homologues of multisensory vestibular cortex areas identified in the monkey and correspond to the parieto-insular vestibular cortex (PIVC), the visual temporal sylvian area (VTS) and areas 7 and 6. We set out to investigate the effects of low doses and high homeopathic potencies of hepatitis c treatment pegylated interferon and ribavirin side cadmium chloride, respectively, in an intoxication model with human primary lymphocytes compared to a human leukemia cell line (Jurkat).

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