on all orders above $300.00

FREE Pills!


for free with every order



Less than in your
local pharmacy

Search by letter:


Enter coupon: (if you have one)

Trimexazol (Bactrim)

Trimexazol injection, a sterile solution for intravenous infusion only, is a combination of sulfamethoxazole, a sulfonamide antimicrobial, and trimethoprim, a dihydrofolate reductase inhibitor antibacterial. Each 5 mL contains 80 mg trimethoprim (16 mg/mL) and 400 mg sulfamethoxazole (80 mg/mL) compounded with 40% propylene glycol, 10% ethyl alcohol and 0.3% diethanolamine; 1% benzyl alcohol and 0.1% sodium metabisulfite added as preservatives, water for injection, and pH adjusted to approximately 10 with sodium hydroxide.

Other names for this medication:
Bactrim, Actrim, Astrim, Bacin, Bacta, Bactelan, Bacterol, Bacticel, Bactiver, Bactoprim, Bactricid, Bactrimel, Bactron, Bactropin, Baktar, Bakton, Balkatrin, Berlocid, Betam, Bioprim, Biotrim, Biseptol, Bitrim, Ciplin, Cotrim, Cotrimoxazol, Cotrimstada, Cozole, Deprim, Dhatrin, Diseptyl, Ditrim, Doctrim, Drylin, Ectaprim, Eusaprim, Fisat, Gantrisin, Globaxol, Kepinol, Lagatrim, Lapikot, Letus, Licoprima, Linaris, Megaset, Meprim, Methoxasol, Metrim, Neoset, Nopil, Novotrim, Organosol, Pehatrim, Primadex, Primazol, Primazole, Primotren, Purbac, Resprim, Sanprima, Sepmax, Septra, Septran, Septrin, Sinersul, Soltrim, Spectrem, Suftrex, Sulfa, Sulfamethoxazole, Sulfametoxazol, Sulfatrim, Sulotrim, Sulprim, Sumetrolim, Suprim, Sutrim, Tagremin, Theraprim, Tmps, Trifen, Trimesulf, Trimesulfin, Trimexazol, Trimezol, Trimol, Trimoxsul, Trisul, Trizole, Urisept, Vanadyl, Wiatrim, Xepaprim,

Similar Products:
Multigram, Noroxine, Sobelin, Tamsudil, Liondox, Samnir, Cefzone, Omag, Kilox, Gabator, Clinsol, Metryl, Azelone, Mebendazole, Dermabel, Tetrex, Simeprevir, Gastral, Axepta, Virucid, Hiderax, Nemasole, Norsec, Ivermectin, Vikrol, Azen, Menova, Citapram, Lokit, Sesaren, Medoflucon, Silenor, Neoset, Pratiprazol, Fokusin, Norzol, Zipant, Zithromax, Flubiotic, Telfexo, Intagra, Methoxasol,

trimexazol f tablets apple

This review summarizes current knowledge on the role of stress in development of hypertension with a special focus on the interactions among NO and other biological systems affecting blood pressure and vascular function. Tissue blood exchange and tissue oxygen tension in relation to total body oxygen consumption in experimental surgical shock. Severe acute respiratory syndrome (SARS) is a contagious viral illness first recognized in late 2002. Reducing leg oedema after femoro-popliteal bypass surgery: a challenge. A food trace-back investigation found that the only exposure common to all cases was consumption of raw whitebait imported from Indonesia.

trimexazol f tablets en walmart

Separation of low-molecular-weight purine electro-oxidation products from phosphate buffers. We analyzed our experience with MRI of pelvic acute hematogenous osteomyelitis (AHO) to address the following questions: What does MRI reveal about bone involvement?

trimexazol f tabletas next tabs

Synaptotagmin and complexin ensure fast synchronous calcium-evoked neurotransmitter release. Consortium for oral health-related informatics: improving dental research, education, and treatment. A well-known turnover process of membrane FasL is mediated by matrix metalloproteinase, which generates soluble FasL (sFasL).

trimexazol f tablets apple

Cell proliferation in organs of rats bearing hepatoma 3924A: effects of X-rays of surgery. Holiday destinations now include once-remote regions such as subSaharan Africa and New Guinea. The sections were stained using haematoxylin and eosin, Fontana-Masson, diastase-resistant periodic acid-Schiff, Masson trichrome and Verhoeff-van Gieson stains, and immunostaining for melanocytes. The inhibitory effect of angiotensin II (Ang II) is rapid and transient, and affects both ERK1 and ERK2 (extracellular signal-related protein kinase) isoforms of the enzyme.

trimexazol suspension para que sirve

Melanoma and pregnancy an experimental evaluation of a clinical impression. This material meets the established criteria for pulmonary surfactant.

trimexazol f tabletas next tabs

states between social capital (as measured by mutual trust and civic engagement) and firearm availability. Spontaneous regression of Kikuchi lymphadenopathy with oligoclonal T-cell populations favors a benign immune reaction over a T-cell lymphoma. This study investigated the effect of vowels and context on the reading accuracy of poor and skilled native Arabic readers in reading paragraphs, sentences, and words.

trimexazol f tabletas next tabs

The objective of this study was to determine the outcome of pregnancy in post-term cases compared with term cases in a well defined population receiving modern obstetric care. The substrate AdoMet adopts a bent shape that directs the activated methyl group toward the active site near the catalytic DPPY motif.

trimexazol f tabletas next tabs

The effect of amphetamine on head and eye movements following vestibular stimulation in squirrel monkeys. A large rehabilitation hospital in the Spinal Cord Injury Model Systems. The relation between ventricular breadth and cranial breadth in the pneumoencephalogram. Cerebral blood flow was determined after intravenous injection of H2O, labeled with the positron-emitting isotope, 15O (oxygen 15).

trimexazol f tabletas next tabs

This indicates that the subcellular protein distribution contributes to in vivo ADP-ribosylation by ExoS. PET CBF maps were generated by using the autoradiographic method.

drug reaction rash bactrim

  • buy bactrim sulfamethoxazole trimethoprim
  • generico do bactrim for ear
  • bactrim syrup cmi stock
  • bactrim antibiotic over the counter
  • fixed drug eruption bactrim antibiotic side
  • trimexazol iv
  • bactrim syrup 50 ml equals how many ounces
  • treating a uti with bactrim f
  • bactrim for mrsa skin infection
  • dosage bactrim for uti
  • bactrim ds side effects long-term use
  • pneumocystis jiroveci treatment bactrim suspension
  • bactrim allergy ancef antibiotic
  • trimexazol f tabletas next tabs
  • actonel renal dosing bactrim
  • ceporexin duo suspension posologia bactrim
  • bactrim allergy furosemide
  • bactrim 800/160 tabs
  • bactrim pills side effects
  • erythromycin for uti dosage bactrim
  • cefoperazone renal dose bactrim
  • prostavar rx dosage for bactrim
  • antibiotics for uti bactrim how long to work
  • bactrim ds in pregnancy
  • bactrim over counter
  • bactrim dose pediatric
  • bactrim pregnancy safe
  • biaxin and pcn allergy bactrim
  • bactrim in pregnancy
  • what is allopurinol dress syndrome bactrim
  • bactrim suspension dosis recomendada
  • mrsa resistance to bactrim antibiotic
  • cleocin renal dosing for bactrim
  • sultamicillin renal dose bactrim
  • septra bactrim acne side
  • trimexazol f tablets en walmart
  • bactrim septra drug information
  • bactrim suspension pediatrica presentacion
  • uro bactrim forte precious memories
  • rocephin for uti dose bactrim
  • is bactrim over the counter drug
  • antibiotic bactrim septra side effects
  • lovenox prescription example for bactrim
  • bactrim pill pictures
  • ambisome renal dosing for bactrim
  • allergic reaction to bactrim treatment for strep
  • cyclosporine renal dose bactrim
  • bactrim antibiotic for uti dose
  • bactrim ds liquid dosage
  • shigella treatment bactrim for acne
  • 10 smz/tmp ds 800-160 tab generic for bactrim ds 800-160 tab
  • bactrim dose for ear infection
  • resistant lice bactrim and alcohol
  • john bactrim for uti
  • amicar dosing information for bactrim
  • trimexazol f tablets apple
  • dosage of bactrim ds for mrsa
  • ds bactrim dose uti
  • p acnes bactrim antibiotic uses
  • bactrim medication classification
  • bactrim antibiotic and pregnancy
  • bactrim dose for uncomplicated uti tx
  • drug reaction rash bactrim
  • lacteol capsule posologia bactrim
  • mrsa treatment with bactrim allergy how long does it last
  • bactrim dose dogs
  • bactrim ds 800-160 tab dosage
  • bactrim allergic reaction hives rash
  • is bactrim a cephalosporin antibiotic injection
  • bactrim for uti dosage and length
  • augmentin vs bactrim for sinus infection
  • trimexazol suspension para que sirve
  • bactrim suspension dosing calculators
  • neobrufen 600 mg posologia bactrim
  • chanson roland bactrim dosage
  • bactrim ds 800-160 side effects
  • bactrim side effects rash treatment
  • maxolon renal dose bactrim

trimexazol f tablets apple

Mechanisms of induction and identity formation in brain development Vestibulo-oculo-motor neurons were identified by antidromic stimulation of the ascending medial longitudinal fasciculus (MLF). A critical minimum value of 1.3 for S0/X0 and a maximum value of 0.1 for S0/KS were suggested to establish the testing criteria for the kinetic study under the respirometric conditions.

trimexazol f tablets en walmart

Glucocorticoid metabolism and adrenocortical reactivity to ACTH in myotonic dystrophy. In experiments on random-bred white male mice it was shown that medicinal agents, applied for various purposes in dermatoplasty operations, exert different influence on the size of necrosis of a skin flap on a feeding pedicle. Clinical application of spectroscopic imaging could arise from the capability to differentiate between early lesions that might respond to therapy and older irreversible lesions.

trimexazol f tablets en walmart

High titres of antibodies against rubella and morbilli virus in patients with chronic hepatitis. To investigate the possible effects on carbohydrate absorption, the sucrose content of the gastrointestinal tract was examined in 12 h fasted rats after an oral sucrose load (2.5 g/kg body weight). Clinical significance of ankle systolic blood pressure following exercise in assessing calf muscle tissue ischemia in peripheral artery disease.

trimexazol f tablets apple

The purpose of our study was to design simple computer-generated sex-based charts to enhance the evaluation of skeletal maturation, especially when frequent assessments are made. Liver biopsy (LB) is the only means to evaluate fibrosis in NAFLD. Energy-filtering transmission electron microscopy permits the detection of specific elements within such compartments.

trimexazol f tablets apple

The results of the studies support our earlier model that an L-shape molecular array is essential for eliciting sweet taste. The physiological association of beta(t) with HTA 1 was confirmed by the substantial increase of beta(t) which parallels the increase of HTA 1. Unique among the phospholipase C isozymes, the recently identified phospholipase C-epsilon (PLC-epsilon) contains an amino-terminal CDC25 domain capable of catalyzing nucleotide exchange on Ras family GTPases as well as a tandem array of Ras-associating (RA) domains near its carboxyl terminus that are effector binding sites for activated H-Ras and Rap.

bactrim suspension dosis recomendada

Affymetrix-based profiling of a human preadipocyte cell line identified several members that are differentially regulated during cell differentiation. The aim of this study was to elicit societal preferences for the symptom burden associated with moderate to severe allergic asthma. Evaluation of the hydrogen bond energy of base pairs formed between substituted 9-methyladenine derivatives and 1-methyluracil by use of molecular orbital theory. The prevalence of BRAF, NRAS, and p16CDKN2A mutations during melanoma progression remains inconclusive. The effects of age and emotional acceptance on distress among breast cancer patients.

bactrim dose for uncomplicated uti tx

Longitudinal studies to examine the long-term outcome of bariatric surgery and the prognostic indicators are needed. Circadian rhythms and the circadian organization of living systems. Genetic characterization of HIV type 1 from migrant workers in three South African gold mines. Patients were randomised to CT within one hour of admission or supine abdominal and erect chest radiography.

drug reaction rash bactrim

Immunoprecipitation using mAb 16a1 isolated a protein with amino acid peptide sequences matching MPT51 from the cytosol. Angiogenesis, which is essential for tumor growth, is regulated by various angiogenic factors. Infections due to Coxsackie virus group A, type 9, in Boston, 1959, with special reference to exanthems and pneumonia. We can also evaluate the laterality of intracranial hemodynamics using PF. These observations support the hypothesis that platelet surface glycoprotein loss is a continuous process in the normal circulation which may occur during reversible contact interactions in the process of hemostasis and thrombosis.

bactrim dose pediatric

CDI and BFI cineloops were prepared off-line and both optimal and suboptimal (increased color artifacts) images were presented in random order to four observers. Curvilinear EUS examination of the left hepatic lobe in addition to standard radial EUS examination can be performed safely when staging cancer of the esophagus and cardia. They also reported having more health problems, including high blood pressure, high blood sugar, high cholesterol, and overweight.

trimexazol f tablets apple

It is suggested that studies so far have concentrated on analysing the weight loss results to the detriment of examining the nature of changes effected in behavior. Image processing software can be used to estimate the area and volume of fat and separate the fat and water signals at a visually optimal threshold in the MR image, which requires contrast enhancement between intestinal contents and visceral fat. The agreement between lay person and expert was good with only 6 items in total changed by the expert.

bactrim dose pediatric

The study suggests that transcription factors responsible for the observed expression pattern in breast cancers may lead us to important biological pathways. After an intravenous bolus injection of Definity, the area of central echolucency within the mass was opacified compatible with a vascular origin. Gene expression profiles revealed that the liver was in an inflammatory state characterized by up-regulation of positive acute phase protein genes, irrespective of the target cells exposed to radiation.

pneumocystis jiroveci treatment bactrim suspension

This suggests that the microcirculation may be a key target of H. Therefore, gum chewing may benefit children with ADHD in situations requiring particular cognitive efforts. Double-blind controlled trial of gabapentin in essential tremor. This review describes the rationale for designing drugs based on symphobodies against pathogenic viruses, including HIV, vaccinia and smallpox virus, and respiratory syncytial virus. We screened a cDNA library generated from unselected cells from the knee joint of a 62-year-old white female with long-standing RA.

prostavar rx dosage for bactrim

NMR-detected perturbations in CYP101 upon Pdx binding encompass regions of the CYP101 remote from the putative Pdx binding site, including in particular a region of the CYP101 molecule that has been implicated in substrate access to the active site via dynamical processes. This in vivo ultrastructural study of anaerobic spiral-shaped organisms bypasses the difficulties of in vitro culture techniques and provides a detailed description and identification of these organisms in their host environment.

fixed drug eruption bactrim antibiotic side

Grey matter abnormalities in first-episode schizophrenia and affective psychosis. It is highly expected that the promising results will be obtained and the application of several kinds of lymphokines such as IL2 to clinical fields will become possible. Such absorption, which has been found in reptilian proximal tubules, may be very important for osmoregulation in all birds and uricotelic reptiles and may provide insight into the mechanism of fluid absorption in mammals.

prostavar rx dosage for bactrim

In addition, the granulation tissue formed around the implant was loosely organized, and the surrounding tissue had integrated well with the implant. Data were collected from 1,115 adolescent athletes from 12 outpatient physical therapy clinics in a single healthcare system. There has been an increasing amount of data linking higher levels of the pentraxin PTX3, a long pentraxin, to embryo implantation. H1N1 vaccination can cause false-positive FDG PET/CT findings, when administered less than 14 days before the test, with the highest probability if the vaccination was administered less than 8 days ago. Community-wide, cross-sectional telephone surveys of Vietnamese women in SCC (intervention community) and Harris County, Texas (comparison community) measured overall project impact.

bactrim ds 800-160 tab dosage

Significance of laboratory and radiologic findings for differentiating between septic arthritis and transient synovitis of the hip. Differential expression of mouse orexin receptor type-2 (OX2R) variants in the mouse brain. Diagnostic value of epileptic seizures for location and morphology of brain neoplasms. Ozonisation coupled with biological degradation for treatment of phenolic pollutants: a mechanistically based study. There was no correlation between the area of the mucous glands and age.

john bactrim for uti

Interlabial masses in little girls: review and imaging recommendations. Thirty-nine raw milk samples and 11 pasteurized product samples were collected to represent the processing continuum from incoming truck loads of raw milk to packaged products.

bactrim antibiotic and pregnancy

Use of stereoscopic vision for analysis of digital X-ray images of lungs The role of mitochondria in cellular iron-sulfur protein biogenesis and iron metabolism. It is reported here that ECP induced apoptosis of monocytes over a period of at least 48 hours. Based on available evidence from randomized controlled trials and meta-analysis, the perioperative administration of pregabalin reduces opioid consumption and opioid-related adverse effects in the first 24 h following surgery.

sultamicillin renal dose bactrim

Data analyses included the constant comparative method consistent with the grounded theory approach. However, high maternal deaths from haemorrhage and anaemia raise questions about the quality of detection and treatment of anaemia at field antenatal clinics, which is the primary care setting for pregnant women. The classification of the physical and chemical factors of growth neurites regulation is given. 20 patients in the sensitive group had statistically higher levels of total serum IgE, higher levels of specific IgE anti-ragweed antibodies, and greater leukocyte sensitivity as measured by antigen-induced histamine release than did eight patients in the insensitive group.

trimexazol f tablets en walmart

The case of a 16-year-old boy is reported who underwent surgery for the excision of an Askin tumor and has subsequently undergone six excisions of local Askin tumor recurrences, with follow-up postoperative chemo- and radiotherapy over a 7-year period. Hemorrhagiparous malignant dysglobulinemia of reticulo-plasmocyto-sarcomatous type We have performed tight-binding band structure calculations for the surface layer. Discernible effects between heat shock and C2-ceramide treatments were observed in cellular changes such as total protein synthesis, HSP synthesis, stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) activity and PARP cleavage. The second ES program lasted for one week and involved 15 minutes of ongoing ES of bilateral hip adductor and abductor muscles at the sensory and motor levels, respectively, during walking for three sessions a day for the week.

bactrim over counter

Thromboxane synthase from bovine lung--solubilization and partial purification. Significance of delta agent infection in chronic hepatitis B virus infection: a study in British carriers. Therefore, individuals with this disorder possess an intrinsic B cell dysfunction that is not related to abnormal T cell regulation. Swelling at the angle of the mandible: imaging of the pediatric parotid gland and periparotid region.

bactrim pills side effects

Higher dose SCC intermittent therapy given in thrice weekly (2E3H3R3Z3, 4H3R3) has now been advocated by WHO and implemented by the Revised National TB Control Programme. Psychoneuroimmunology is a relatively young field of research that investigates interactions between central nervous and immune system.

prostavar rx dosage for bactrim

Tissue distribution, turnover, and glycosylation of the long and short growth hormone receptor isoforms in rat tissues. In this model, new infections and recoveries are assessed by the daily inoculation rate and are subject to laws of chance.

 Show Hide 
pneumocystis jiroveci treatment bactrim suspension 2010-09-15

To describe the buy generic propecia online uk mail mortality during the subsequent 10 years for subsets of patients hospitalised for suspected acute coronary syndrome. There is evidence that patients with TNBC may have a greater probability of obtaining some kind of clinical efficacy benefit from bevacizumab-based therapy.

bactrim for uti dosage and length 2010-07-26

Here we present evidence that the expression of C/EBPalpha in old rats (24 months) differs from its expression in young animals (6-10 months) during liver regeneration. This prospective study evaluated the prevalence and clinical outcome of CMV infection in patients gastrolan lansoprazole dosage with new onset UC who have not been exposed to UC medication. Our group has also conducted several retrospective studies, and Phase I and II trials independent of the JCOG Data Center. Once contact with signalled avoidance was made, subjects continued responding to remain in that condition. Determination of the optimum treatment for sacral giant cell tumour will require randomized controlled trials.

fixed drug eruption bactrim antibiotic side 2018-02-23

Hypothenar hammer syndrome: a discrete syndrome to be distinguished from hand-arm vibration syndrome. Although conventional colonoscopy is medicine nexium esomeprazole contra the most sensitive test available for the investigation of the colorectum for polyps, there are data that raise concerns about its sensitivity. The apoptotic cells were detected with the method of in situ end-labeling of DNA fragments. This data set was used to create logical models of the signaling events underlying the observed expression changes produced by various cancer genes and allowed to uncover unknown and verifiable interactions. Regionally differing geometrical remodelling occurs early in HTN.

bactrim dose for uncomplicated uti tx 2018-12-04

The findings support progressive transformation of mucous-neck cells into chief cells. Percutaneous fetal endoluminal tracheal occlusion is expected to become an effective vigora 100 price in mumbai news and minimally invasive treatment for fatal lung hypoplasia due to CDH.

cleocin renal dosing for bactrim 2013-08-14

Greater awareness of agents with such potential for danger needs to be available to health care providers, and the taking of such remedies should always be discussed with the supervising physician. The aim of the present study was to evaluate the relationship between ERalpha PvuII and XbaI polymorphisms and serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), C-reactive protein (CRP) and homocysteine in postmenopausal women. The need exists for a safe, easy flutamide package insert pdf to use, and effective hemostatic technique to replace the labor-intensive method of manual compression. A prospective clinical non-randomized trial of 55 patients with primary snoring followed over a period of 3 years.

bactrim dose pediatric 2018-07-06

Effects of recycling on metallic direct-bond orthodontic brackets. This article compared conventional intracoronal cast restorations with a design based on resin-bond retention. The study participants were patients who presented for treatment of an injury. On the other hand, folded chromosomes from cdc 28 in sporulation medium at the restrictive temperature appear unstable, while chromosomes from cdc 25 are stable. The forcid 1000 mg cena intensity of lysosomal labeling was intermediate between that of RER and Golgi apparatus.

bactrim suspension dosis recomendada 2010-07-29

Structures of the recurrence plot of heart rate variability signal as a tool for predicting the onset of paroxysmal atrial fibrillation. The results show that our proposed method yields a promising result with better average accuracy and quantisation errors compared to the other methods victrelis vs telaprevir and boceprevir as well as convincing significant test.

bactrim ds liquid dosage 2016-01-29

This proposition is based on published observations that the unexpected and unexplained clinical benefits produced by statins have also been shown to be properties of vitamin D. These changes were accompanied by a local increase in the proteolytic enzymes, MMP-2 and MMP-9. Diagnosis and localization of cerebral tumors by means of radioactive diiodofluorescine However, these procedures may mask neurologic deterioration, delay treatment, and ethambutol hcl obat apa dexamethasone prolong rehabilitation. Silver-permanganate method to demonstrate axis cylinders and myelin sheaths on frozen sections.

john bactrim for uti 2010-02-12

Lymphocytes from athymic and normal mice were tested and compared for cytotoxic activity after in vitro cultures supplemented with concanavalin A or T-cell growth factor (TCGF). A comparative study of the profile of 4 and 1 toward metabotropic (CB1, CB2) and af warfarin dose inr ionotropic (TRPV1, TRPV2, TRPM8, TRPA1) targets of phytocannabinoids showed that prenylogation increased potency toward CB2 by ca. Outcomes following 50 consecutive endoscopic gastrojejunal revisions for weight gain following Roux-en-Y gastric bypass: a comparison of endoscopic suturing techniques for stoma reduction. However, the most favorable effect of these therapies is the slowing of the vision loss.

bactrim medication classification 2010-08-06

The disappearance of endogenously labeled fibronectin from plasma and its subsequent extravascular localization was studied over a 38-h period in normal rats (350-400 g) utilizing plasma fibronectin labeled in vivo with 75Se-selenomethionine. The case of a patient with clarithromycin allergy penicillin augmentin severe left main trunk disease is presented, in which spasm of the right coronary artery resulted in intraoperative myocardial ischemia and perioperative myocardial infarction.

bactrim suspension pediatrica presentacion 2013-07-03

The authors present two cases of extensive and very deep electrical burns of the skull, involving the dura and producing neurological complications. A review of past experience with piloted missions has shown that gradual breakdown in bone and muscle tissue, together with fluid losses, despite a vigorous exercise regimen can ultimately lead to increased clonamox overdose exo evidence of renal stones, musculoskeletal injuries, and bone fractures. Isolation of pigment protein complexes revealed that the majority of high-light-synthesized diadinoxanthin and diatoxanthin is associated with the fucoxanthin chlorophyll protein (FCP) complexes. An inverse relationship between these two biomarkers was observed through correlation analysis. External feeding is an ancestral trait from which internal feeding evolved independently several times.

is bactrim a cephalosporin antibiotic injection 2010-07-09

MHC class II molecules on the move for successful antigen presentation. All combinations of T and B cell subsets from loseprazol 20 mg cena normal C57BL/6 mice failed to generate vigorous IgM and IgG secretion.